PMID: 48729May 10, 1975Paper

New complement-fixation test for the human reovirus-like agent of infantile gastroenteritis. Nebraska calf diarrhea virus used as antigen

A Z KapikianR M Chanock


A complement-fixation (C.F.) test for the human reovirus-like agent of infantile gastroenteritis has been developed using the serologically related Nebraska calf diarrhoea virus (N.C.D.V.) as antigen. Most infants and children who shed the agent in stools and/or who demonstrated serological (C.F.) evidence of infection with a reovirus-like-particle-positive human stool-filtrate C.F. antigen also demonstrated serological evidence of infection when a concentrated N.C.D.V. preparation was employed AS C.F. antigen. The N.C.D.V., which was previously shown to be related to the human reovirus-like agent, was found to be related antigenically to the epizootic diarrhoea of infant mice (E.D.I.M.) virus also. Studies on the prevalence of C.F. antibody in sera from infants and young children revealed a pattern of rapid acquisition of antibody to both the human reovirus-like agent and the N.C.D.V. as over 80 percent of these individuals possessed antibody to each agent by 36 months of age. A strong positive association was found in the results obtained with the two antigens. The ready availability of cell-culture grown N.C.D.V., and its ability to serve as a "substitute" C.F. antigen for the human reovirus-like agent, should enable the ser...Continue Reading


Jan 4, 1975·Lancet·C A MorrisH Davies
Dec 29, 1973·Lancet·T H FlewettH Davies
Jun 29, 1974·Lancet·J G CruickshankO F Webster
Aug 10, 1974·Lancet·M SextonB J Ruck
Sep 14, 1974·Lancet·I H HolmesS J Baker
Nov 2, 1974·Lancet·I OrstavikJ C Ulstrup
Sep 21, 1974·Lancet·G B WhiteH E Parry

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