New concepts: growth hormone, insulin-like growth factor-I and the kidney

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
R Rabkin, Franz Schaefer

Abstract

Both growth hormone (GH) and IGF-1 have major effects on normal kidney growth, structure and function and participate in the pathogenesis of certain kidney diseases. Furthermore when the kidneys fail there are profound changes in the circulating GH-IGF-1 system and the renal and systemic responses to these hormones. In this brief review we address the advances that have been made in our understanding of the relationship between growth hormone GH and IGF-1 and the kidney in health and the systemic and local perturbations that occur in kidney disease and identify key unanswered questions.

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Citations

Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ralph RabkinFranz Schaefer
Feb 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jane C Tan, Ralph Rabkin
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Dec 31, 2010·Kidney International·Joaquin EscribanoRicardo Closa-Monasterolo
Aug 25, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Daniel LandauRalph Rabkin
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Oct 24, 2014·American Journal of Physiology. Renal Physiology·Oleg ZaikaOleh Pochynyuk

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