PMID: 11317050Apr 24, 2001Paper

New concepts in necrotizing enterocolitis

Current Opinion in Pediatrics
M S Caplan, T Jilling

Abstract

Necrotizing enterocolitis is an overwhelming gastrointestinal emergency that primarily afflicts premature infants born weighing less than 1500 g. Despite years of investigation, the etiology remains unclear, and accepted prevention and treatment strategies are lacking. Studies published over the last year have provided new insight into several aspects of this complex disease. In this review, novel information is presented on (1) the epidemiology; (2) methods of early diagnosis, such as abdominal magnetic resonance imaging; (3) the importance of risk factors, including assessment of feeding strategies and role of bacterial colonization; (4) the pathophysiology, highlighting experimental and clinical trials evaluating the role of inflammatory mediators and growth factors on the disease; (5) preventive strategies, such as anaerobic bacterial supplementation; and (6) surgical interventions, including peritoneal drainage. Understanding some of these important aspects of necrotizing enterocolitis may help improve the outlook of patients with this dreaded disease. Although the incidence of neonatal necrotizing enterocolitis (NEC) and the mortality stemming from this disease have not significantly improved over the last 30 years, there...Continue Reading

References

Dec 22, 1990·Lancet·A Lucas, T J Cole
Jul 1, 1990·The Journal of Pediatrics·R M Kliegman
Jul 7, 1988·The New England Journal of Medicine·M M EiblA Rosenkranz
Oct 1, 1994·The Journal of Applied Bacteriology·G R Gibson, X Wang
Jan 1, 1996·Annual Review of Physiology·B E Sands, D K Podolsky
Mar 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·M S CaplanW Hsueh
Feb 18, 1998·American Journal of Obstetrics and Gynecology·M OkamuraY Tomoda
Feb 9, 1999·European Journal of Pediatrics·C S PeterC F Poets
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·I H GewolbP Panigrahi
Jul 8, 1999·Biology of the Neonate·J LinM W Babyatsky
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A B Hoyos
Jan 6, 2000·American Journal of Reproductive Immunology : AJRI·M D SrivastavaB I Srivastava
Feb 29, 2000·Journal of Pediatric Surgery·C E ShinB W Warner
Feb 29, 2000·Journal of Pediatric Surgery·D J Ledbetter, S E Juul
Mar 4, 2000·Pediatrics·E F MaaloufA D Edwards
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·N N NanthakumarW A Walker

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Citations

Jun 22, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S BagciA Mueller
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michelle J AlfaGodfrey K M Harding
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Jing LinMark W Babyatsky
Mar 24, 2005·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Christian Con Yost
Oct 2, 2008·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Brigit M Carter, Diane Holditch-Davis
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ann E ThompsonSteven M Opal
Mar 5, 2008·The Pediatric Infectious Disease Journal·Soyhan BagciAndreas Mueller
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Jul 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melissa D HalpernBohuslav Dvorak
Mar 22, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jing LuTamas Jilling
Jun 29, 2007·Pediatric Research·Rob M J MoonenEduardo Villamor
Apr 10, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mmaphuti J ChokoeJohan Smith
Jan 29, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·R SinghD M Kent
May 5, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·E PolycarpouD Kafetzis
Jun 1, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·M L StoneK D Fairchild
Jul 10, 2012·Pediatrics and Neonatology·Shu-Fen WuHung-Chih Lin
Dec 19, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Jixin YangGail E Besner
Apr 25, 2013·Seminars in Pediatric Surgery·Kathryn J RowlandBrad W Warner
Jul 24, 2012·Seminars in Perinatology·Rachana SinghIvan D Frantz
Jun 28, 2007·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Brigit M Carter
Feb 16, 2010·Journal of Pediatric Surgery·Jonathan Saul KarpelowskyAlastair J W Millar
Apr 14, 2009·Journal of Pediatric Surgery·Ori RonNiyi Ade-Ajayi
Dec 11, 2007·Veterinary Immunology and Immunopathology·C T CollierH R Gaskins
Jul 17, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ronald J McPherson, Sandra E Juul
Aug 9, 2005·Seminars in Pediatric Surgery·Brad W Warner, Barbara B Warner
Aug 9, 2005·Seminars in Pediatric Surgery·Marion C W Henry, R Lawrence Moss
Mar 27, 2007·The Journal of Pediatrics·Barbara B WarnerBrad W Warner
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andreas PascherAndrea R Mueller
Oct 21, 2006·Paediatric and Perinatal Epidemiology·Robert C HolmanLawrence B Schonberger
Jan 3, 2013·American Journal of Reproductive Immunology : AJRI·Sun K KimTinnakorn Chaiworapongsa
Aug 10, 2011·Emergency Medicine Australasia : EMA·Davinder Gill
Sep 23, 2014·Evidence-based Child Health : a Cochrane Review Journal·Khalid AlFaleh, Jasim Anabrees
Jul 31, 2004·Seminars in Perinatology·Marion C W Henry, R Lawrence Moss
Dec 31, 2002·Biochemical and Biophysical Research Communications·Marilynn A LarsonThomas L McDonald

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