New concepts in neonatal seizures

Neuroreport
G L HolmesYehezkiel Ben-Ari

Abstract

The immature brain is more prone to seizures than the older brain as a result of an imbalance between excitatory and inhibitory input. The depolarizing, rather than hyperpolarizing effect of GABA(A) during the first week of life in the rodent, and the delay in postsynaptic GABA(B) inhibition coupled with the over-expression of glutamatergic synapses contribute to this increased propensity toward seizures. It is now clear that seizures can be injurious to the immature brain, although the pattern of seizure-induced injury is age-related. While the immature brain is resistant to acute seizure-induced cell loss, there are functional abnormalities following seizures with impairment of visual-spatial memory and reduced seizure threshold. Neonatal seizures are also associated with a number of activity-dependent changes in brain development including altered synaptogenesis and reduction in neurogenesis. These results argue that neonatal seizures should no longer be considered as benign events.

References

Aug 1, 1978·Neuropädiatrie·C G Wasterlain
Feb 21, 1992·Brain Research. Developmental Brain Research·C E StafstromG L Holmes
May 15, 1992·Science·G BuzsákiK Wise
Jan 1, 1991·Annals of the New York Academy of Sciences·J W SwannR J Brady
May 20, 1991·Brain Research. Developmental Brain Research·E F SperberS L Moshé
Jun 1, 1991·Annals of Neurology·F E JensenJ L Burchfiel
Jan 1, 1990·Advances in Experimental Medicine and Biology·J W SwannR J Brady
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·M Constantine-Paton
Nov 1, 1990·Annals of Neurology·P R Huttenlocher, R J Hapke
Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Dec 15, 1987·Brain Research·E A CavalheiroL Turski
Feb 1, 1986·Pediatric Clinics of North America·M J PainterP Crumrine
Jul 1, 1973·Archives of Neurology·C G Wasterlain, F Plum
Dec 1, 1983·Annals of Neurology·I BergmanR David
Mar 1, 1984·Brain Research·B J AlbalaR Okada
May 1, 1982·Brain Research·S L Moshé, B J Albala
Jan 1, 1981·Developmental Psychobiology·S L Moshé
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P E BicklerB M Hansen
Jul 15, 1996·The Journal of Physiology·G ChenA N van den Pol
Sep 2, 1996·Brain Research. Developmental Brain Research·J C NeillG L Holmes
Nov 15, 1996·Science·L C Katz, C J Shatz
Dec 23, 1996·Brain Research. Developmental Brain Research·Z LiuG L Holmes
Dec 23, 1996·Brain Research. Developmental Brain Research·J D MarksG G Haddad
Jan 29, 1997·European Journal of Pharmacology·I KhalilovY Ben-Ari
Jun 1, 1997·Epilepsia·C G Wasterlain
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall

❮ Previous
Next ❯

Citations

Aug 9, 2003·Brain & Development·Silvia PatriziFederico Allemand
Oct 26, 2002·Epilepsy Research·Byung Ho ChaGregory L Holmes
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Janet Rennie, Geraldine Boylan
Oct 7, 2003·Annual Review of Neuroscience·Jeffrey L Noebels
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian YangRoland S G Jones
May 30, 2014·Journal of Mathematical Neuroscience·Caroline HartleyLuc Berthouze
Feb 9, 2011·European Journal of Pediatrics·Lieven Lagae
Oct 4, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Eung-Kwon PaeRonald M Harper
Apr 8, 2011·Epilepsy Research·Marat Minlebaev, Rustem Khazipov
Jan 2, 2016·Pharmacological Reports : PR·Ashish Dhir, Vishal Chavda
Aug 26, 2009·Neurobiology of Disease·Samuel GreggioJaderson C Dacosta
Nov 18, 2006·Lancet Neurology·Yehezkel Ben-Ari, Gregory L Holmes
Feb 27, 2004·The European Journal of Neuroscience·Roustem KhazipovGregory L Holmes
Mar 27, 2007·Acta Paediatrica·C M L LommenS Bambang Oetomo
Mar 24, 2006·The European Journal of Neuroscience·Elena IsaevaGregory L Holmes
Sep 18, 2010·The European Journal of Neuroscience·Nadine I HolterAndreas Draguhn
Dec 12, 2012·Epilepsia·Wolfgang Löscher, Michael A Rogawski
Sep 8, 2004·Brain Research. Developmental Brain Research·Javad TowfighiRobert C Vannucci
May 26, 2004·Brain Research. Developmental Brain Research·Genell D HiltonMargaret M McCarthy
Nov 9, 2005·Early Human Development·Matthew Pitt, Ronit Pressler
Dec 3, 2014·CNS Neuroscience & Therapeutics·Roustem KhazipovIlgam Khalilov
May 31, 2014·Neurobiology of Disease·Ozlem AkmanAristea S Galanopoulou
Apr 20, 2006·Arquivos de neuro-psiquiatria·Manoel R R Holanda, Aurea N de Melo
Aug 11, 2007·Journal of Child Neurology·Peter HumphreysEda Wallace
Jul 30, 2017·Epilepsia·John M PellockUNKNOWN Pediatric Epilepsy Academic Consortium for Extrapolation
May 27, 2011·Developmental Neuroscience·Viskasari P KalanjatiStella T Bjorkman
Mar 12, 2013·Epilepsy Currents·Jacqueline A French, Brigid A Staley
May 15, 2003·Endocrinology·Joseph L Nuñez, Margaret M McCarthy
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Dec 3, 2005·Endocrinology·Genell D HiltonMargaret M McCarthy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.