New concepts in organ transplantation

Transplantation Proceedings
K Praditpornsilpa, Y Avihingsanon

Abstract

Long-term graft survival is the desired outcome of organ transplantation. The surrogate metric elimination of acute rejection episodes is not only inadequate but also deceptive, since this freedom does not promise long-term graft survival. Current clinical immunosuppressive agents have reduced acute rejection, but not prolonged graft survival. New paradigms in organ transplantation focus on adhesion-migration events using a selectin antagonist, an antisense oligonucleotide, and FTY 720; on peptide or allochimeric antigens on cytokine disruption, and on inhibition of costimulatory signals. Due to the array of adverse reactions to the available immunosuppressive drugs, these new approaches aim not only to augment long-term graft survival, but also minimize the associated toxicities.

References

Aug 1, 1991·Transplantation·B D KahanS N Sehgal
Feb 1, 1990·Transplantation·J DunnB D Kahan
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Nov 22, 1997·Current Opinion in Immunology·C C Magee, M H Sayegh
May 30, 2001·Transplantation Proceedings·V QuesniauxH J Schuurman

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Citations

Jan 7, 2005·Chemical & Pharmaceutical Bulletin·Shigeo SugiyamaKeitaro Ishii
Apr 4, 2006·American Journal of Veterinary Research·Yi-Je ChenClare R Gregory
Mar 1, 2012·Archiv der Pharmazie·Xiang-Jun FengWei Lu

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