New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2

Immunological Reviews
Monalisa ChatterjiDavid G Schatz

Abstract

The lymphoid-specific factors, recombination-activating gene 1 (RAG1) and RAG2, initiate V(D)J recombination by introducing DNA double-stand breaks at specific sites in the genome. In addition to this critical endonuclease activity, the RAG proteins catalyze other chemical reactions that can affect the outcome of V(D)J recombination, one of which is transposition. While the transposition activity of the RAG proteins is thought to have been critical for the evolution of modern antigen-receptor loci, it has also been proposed to contribute to chromosomal translocations and lymphoid malignancy. A major challenge has been to determine how the transposition activity of the RAG proteins is regulated in vivo. Although a variety of mechanisms have been suggested by recent studies, a clear resolution of this issue remains elusive.

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Nov 2, 2005·Nature Reviews. Immunology·Gary W LitmanLarry J Dishaw
Mar 21, 2009·Genes & Development·Jianbo ZhangThomas Peterson
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Aug 30, 2008·Molecular Cell·Haihui LuMichael R Lieber

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