New concepts on erythema annulare centrifugum: a clinical reaction pattern that does not represent a specific clinicopathological entity

The British Journal of Dermatology
M ZiemerB Zelger

Abstract

Erythema annulare centrifugum (EAC) is considered an inflammatory skin disease with unknown aetiology. In most textbooks it is assigned to the incoherent conglomeration of figurate or gyrate erythemas. To re-evaluate a large cohort of patients with EAC and to assess the evidence for infection with Borrelia. We retrospectively investigated 90 cases with the diagnosis of EAC. Haematoxylin and eosin sections were re-examined and diagnoses were specified; these were then confirmed by clinicopathological correlation. Infection with Borrelia was assessed by focus-floating microscopy and by a Borrelia-specific polymerase chain reaction (PCR). Besides a miscellaneous group of annular disorders at times confused with EAC such as urticaria, leucocytoclastic vasculitis and psoriasis (20 of 90; 22%), EAC appeared to serve as a collective term for three main clinicopathological reaction patterns: (i) (tumid) lupus erythematosus (29 of 90; 32%), (ii) spongiotic dermatitides (25 of 90; 28%) and (iii) pseudolymphoma (16 of 90; 18%). In 13 of 16 (81%) cases with a pseudolymphomatous reaction pattern spirochaetes stained positive but were negative in other reaction patterns of EAC as well as in negative controls. These findings were confirmed by...Continue Reading

References

Aug 1, 1992·Journal of the American Academy of Dermatology·T TsujiS Kimura
Oct 1, 1989·Journal of the American Academy of Dermatology·D C AbeleF W Chandler
Nov 1, 1985·Journal of the American Academy of Dermatology·D J Hogan, K L Blocka
May 1, 1987·International Journal of Dermatology·E Asbrink, A Hovmark
Oct 1, 1987·The American Journal of Dermatopathology·D Tuffanelli
Mar 1, 1988·International Journal of Dermatology·D K Goette, E Beatrice
Jun 18, 1982·Science·W BurgdorferJ P Davis
Nov 1, 1993·The British Journal of Dermatology·M FurueK Tamaki
Mar 14, 2002·The Journal of Dermatology·Kyoung Jin KimJai Kyoung Koh
Sep 1, 1954·A.M.A. Archives of Dermatology and Syphilology·O F JILLISON
Nov 25, 2003·The American Journal of Dermatopathology·Wolfgang WeyersImke Weyers
Jul 16, 2005·Clinical Microbiology Reviews·Maria E Aguero-RosenfeldGary P Wormser
Jan 11, 2007·American Journal of Clinical Pathology·Klaus EisendleBernhard Zelger
Oct 19, 2007·The British Journal of Dermatology·K EisendleB Zelger
Nov 21, 2007·Journal of the American Academy of Dermatology·Bernhard ZelgerBettina Zelger

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Citations

Aug 3, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ZiemerB Zelger
Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Aug 7, 2013·Indian Journal of Dermatology·Sudhir Uk NayakSmitha M Prabhu
Mar 19, 2014·Annales de dermatologie et de vénéréologie·F-Z ElfatoikiH Benchikhi
Nov 29, 2012·The American Journal of the Medical Sciences·Sergio De MarchiSergio Umberto De Marchi
Oct 15, 2011·The Journal of Dermatology·Wang-Cheng Ko, Weir Chiang You
Feb 15, 2011·Actas dermo-sifiliográficas·V FuentelsazF J Carapeto
Mar 18, 2011·Actas dermo-sifiliográficas·J J Ríos-MartínD Moreno-Ramírez
Mar 19, 2016·Journal of Cutaneous Pathology·Carlo Tomasini
Apr 21, 2017·The American Journal of Dermatopathology·Yu-Hung Wu, Pa-Fan Hsiao
Jun 10, 2017·Clinical and Experimental Dermatology·T HashimotoK Iwatsuki
Jun 2, 2012·Dermatitis : Contact, Atopic, Occupational, Drug·Zhiqiang SongFei Hao
Dec 18, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·P Mendes-BastosJ Cardoso
May 29, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander BoehnerJohannes Ring
Jul 22, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander BoehnerJohannes Ring

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