New Copper Compounds with Antiplatelet Aggregation Activity

Medicinal Chemistry
Mirthala Flores-GarcíaAurora de la Peña-Díaz

Abstract

Ischemic heart disease, cerebrovascular accident, and venous thromboembolism have the presence of a thrombotic event in common and represent the most common causes of death within the population. Since Schiff base copper(II) complexes are able to interact with polyphosphates (PolyP), a procoagulant and potentially prothrombotic platelet agent, we investigated the antiplatelet aggregating properties of two novel tridentate Schiff base ligands and their corresponding copper( II) complexes. The Schiff base ligands (L1) and (L2), as well as their corresponding copper(II) complexes (C1) and (C2), were synthesized and characterized by chemical analysis, X-ray diffraction, mass spectrometry, and UV-Visible, IR and far IR spectroscopy. In addition, EPR studies were carried out for (C1) and (C2), while (L1) and (L2) were further analyzed by 1H and 13C NMR. Tests for antiplatelet aggregation activities of all of the four compounds were conducted. X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong intramolecular hydrogen bond. NMR studies show that both ligands are found as enol-imine tautomers in CDCl3 solution. In the solid state, the geometry around the copper(II) ion in both (C1) an...Continue Reading

References

Jan 7, 1999·The Journal of Pharmacy and Pharmacology·Z Q ShenL Duan
Jul 27, 2005·Journal of Cardiovascular Pharmacology·Norma Corona-de-la-PeñaAbraham Majluf-Cruz
Feb 26, 2008·Journal of Inorganic Biochemistry·Vivian Chagas da SilveiraAna Maria da Costa Ferreira
Feb 14, 2009·The American Journal of Cardiology·Lisa K Jennings
Mar 26, 2011·Nature Reviews. Immunology·John W SempleJohn Freedman
Oct 11, 2014·Journal of Thrombosis and Haemostasis : JTH
Jun 17, 2015·Nature Reviews. Cardiology·John A Heit
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·J H Morrissey, S A Smith
Mar 2, 2016·Seminars in Thrombosis and Hemostasis·Thomas GremmelAlan D Michelson
Jul 28, 2016·Journal of Inorganic Biochemistry·Francesco TisatoValentina Gandin
Aug 25, 2016·Current Medicinal Chemistry·Ignacio Esteban LeonSusana Beatriz Etcheverry
May 2, 2017·Bioinorganic Chemistry and Applications·Vasiliki D PapakonstantinouAthanassios I Philippopoulos
Dec 23, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jeffrey I Weitz, James C Fredenburgh
Apr 12, 2018·Physiology·Fred G Pluthero, Walter H A Kahr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.