PMID: 9420329Feb 21, 1998Paper

New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB

Genes & Development
T LagrangeR H Ebright

Abstract

A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involves a fourth core promoter element, the IIB recognition element (BRE), in addition to the TATA element, the initiator element, and the downstream promoter element, and involves a second sequence-specific general transcription factor, IIB, in addition to transcription factor IID.

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Citations

Jun 27, 2007·Chromosoma·Wensheng Deng, Stefan G E Roberts
Apr 4, 2003·Current Opinion in Genetics & Development·Joseph C Reese
Jul 24, 1998·Trends in Microbiology·S D Bell, S P Jackson
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Dec 22, 2007·Genome Research·Thomas AbeelYves Van de Peer
Feb 12, 2004·Eukaryotic Cell·Adele McLeodWilliam E Fry

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