New Corticopontine Connections in the Primate Brain: Contralateral Projections From the Arm/Hand Area of the Precentral Motor Region

Frontiers in Neuroanatomy
R J MorecraftWarren G Darling

Abstract

The ipsilateral corticopontine projection (iCPP) represents a massive descending axon system terminating in the pontine nuclei (PN). In the primate, this projection is well known for its dominant influence on contralateral upper limb movements through the classical cerebrocerebellar circuity system. Although a much weaker contralateral corticopontine projection (cCPP) from motor cortex to the paramedian region has been reported in the non-human primate brain, we provide the first comprehensive description of the cCPP from the lateral motor cortex using high resolution anterograde tract tracing in Macaca mulatta. We found a relatively light cCPP from the hand/arm area of the primary motor cortex (M1), comparatively moderate cCPP from ventrolateral premotor cortex (LPMCv) and a more robust and widespread cCPP from the dorsolateral premotor cortex (LPMCd) that involved all nine contralateral PN. The M1 projection primarily targeted the dorsal pontine region, the LPMCv projection targeted the medial pontine region and LPMCd targeted both regions. These results show the first stage of the primate frontomotor cerebrocerebellar projection is bilateral, and may affect both ipsilateral and contralateral limbs. Clinically, the cCPP origi...Continue Reading

References

Sep 15, 1992·The Journal of Comparative Neurology·R J MorecraftM M Mesulam
Jun 8, 1991·The Journal of Comparative Neurology·J D Schmahmann, D N Pandya
Nov 1, 1973·Journal of Neurophysiology·V B BrooksM Uno
Jan 1, 1997·Progress in Brain Research·P Brodal, J G Bjaalie
Jan 1, 1997·International Review of Neurobiology·J D Schmahmann, D N Pandya
Jun 27, 2000·The Journal of Comparative Neurology·K BurmanI Darian-Smith
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heidi Johansen-BergPaul M Matthews
May 24, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Jul 15, 2003·Neuroreport·Ilka ImmischAndreas Straube
Feb 1, 1962·The Journal of Comparative Neurology·H G KUYPERSJ W FARINHOLT
Sep 16, 2004·The Journal of Comparative Neurology·Jeremy D SchmahmannDeepak N Pandya
Nov 14, 2006·The Journal of Comparative Neurology·Robert J MorecraftGary W van Hoesen
Jun 8, 2007·Journal of Neurophysiology·Marc A PizzimentiRobert J Morecraft
Jul 13, 2007·The Journal of Comparative Neurology·Robert J MorecraftPreston Schneider
Nov 5, 2008·Frontiers in Neuroscience·Trygve B Leergaard, Jan G Bjaalie
Mar 11, 2010·Experimental Brain Research·Elisabeth AnensCharlotte Häger-Ross
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sven BestmannNick S Ward
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaofeng LuMasahiko Takada
Jul 18, 2017·Journal of Visualized Experiments : JoVE·Mikkel Vestergaard OlesenBente Pakkenberg
Jun 15, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Warren G DarlingRobert J Morecraft

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