New crystal forms and amorphous phase of sophoricoside: X-ray structures and characterization

Royal Society Open Science
Cheng XingYang Lu

Abstract

Sophoricoside, which is an isoflavone glycoside found in many plant species, has recently attracted attention because of its anti-fertility activity. One solvent-free form, two solvatomorphs and an amorphous phase of sophoricoside are reported for the first time. X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis and Fourier-transform infrared spectroscopy were used to characterize the different forms. The results show that factors such as crystal symmetry, intermolecular arrangement, conformational flexibility, hydrogen-bonding interactions and solvent incorporation lead to different solid-state forms. An investigation of the transformations of the four forms showed that they can interconvert with each other under certain conditions. Amorphous phase and solvatomorphism were unstable but can improve the solubility of sophoricoside in water.

References

Feb 8, 2005·Nature Biotechnology·Ted Apple
May 25, 2006·International Journal of Pharmaceutics·Changquan Calvin Sun
Jan 30, 2008·Journal of Pharmaceutical Sciences·Harry G Brittain
Mar 17, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yong XuNing Du
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Anna Froelich, Andrzej K Gzella
Jan 1, 2005·Profiles of Drug Substances, Excipients, and Related Methodology·Harry G Brittain
Mar 5, 2016·Journal of Pharmaceutical Sciences·Ningbo GongYang Lu

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Methods Mentioned

BETA
X-ray
differential

Software Mentioned

SHELXL
97
SHELXS
Mercury

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