PMID: 11907157Mar 22, 2002Paper

New cytokine delivery system using gelatin microspheres containing interleukin-10 for experimental inflammatory bowel disease

The Journal of Pharmacology and Experimental Therapeutics
Hiroshi NakaseTsutomu Chiba

Abstract

Interleukin (IL)-10 is an anti-inflammatory cytokine that suppresses the T helper 1 immune response and down-regulates macrophages and monocytes. The therapeutic effect of systemic administration of IL-10 for patients with inflammatory bowel disease, however, has not been satisfactory. We examined whether rectal administration of gelatin microspheres (GM) containing IL-10 (GM-IL-10) prevents colitis in IL-10-deficient (IL-10(-/-)) mice. GM-IL-10 and IL-10 alone were administered rectally. The colon was examined macroscopically and microscopically. IL-12 mRNA expression and CD40 expression in Mac-1-positive cells were also examined. Macroscopic and microscopic examination revealed marked improvement of colitis in IL-10(-/-) mice treated with GM-IL-10. mRNA expression of IL-12 in Mac-1-positive cells in GM-IL-10-treated mice was significantly decreased compared with that in the mice treated with IL-10 alone. Additionally, CD40 expression in Mac-1-positive cells in GM-IL-10-treated mice was decreased more prominently than in mice treated with IL-10 alone. The therapeutic effects of GM-IL-10 were associated with decreased expression of IL-12 mRNA and down-regulation of CD40 expression in Mac-1-positive cells. GM-IL-10 might be usef...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S Freudenthal, R M Steinman
Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Aug 1, 1993·The Journal of Experimental Medicine·M R AldersonM K Spriggs
Jun 1, 1995·Clinical and Experimental Immunology·T KucharzikW Domschke
Jul 17, 1998·The American Journal of Pathology·F AutschbachS C Meuer
Nov 24, 1999·The American Journal of Gastroenterology·E BattagliaG Camussi
Jan 29, 2000·Alimentary Pharmacology & Therapeutics·T KucharzikW Domschke
Jun 2, 2000·Gastroenterology·K L MadsenR N Fedorak
Jun 27, 2000·Gastroenterology·B E Sands

❮ Previous
Next ❯

Citations

Dec 20, 2007·Inflammatory Bowel Diseases·Anouk WaeytensClaude A Cuvelier
Jan 13, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Heather A Arnett, Joanne L Viney
May 1, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sho HanedaIwao Sasaki
Aug 15, 2012·Current Allergy and Asthma Reports·Neil ShahErik-Oliver Glocker
Nov 6, 2004·Current Gastroenterology Reports·Gil Y Melmed, Maria T Abreu
Oct 26, 2002·European Journal of Pharmacology·Xiaoxia ZhouFred Zepp
Jul 11, 2013·World Journal of Gastroenterology : WJG·Gareth J MarlowLynnette R Ferguson
Jul 26, 2003·Expert Opinion on Biological Therapy·Henri BraatDaan W Hommes
Nov 22, 2005·Expert Opinion on Drug Delivery·Filippos Kesisoglou, Ellen M Zimmermann
Oct 24, 2007·Journal of Pharmaceutical Sciences·Yvette Meissner, Alf Lamprecht
Feb 7, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eva-Maria CollnotClaus-Michael Lehr
Nov 28, 2002·Gastroenterology·Karen Madsen
Apr 2, 2014·Journal of Crohn's & Colitis·Angelo ViscidoGiuseppe Frieri
Jun 13, 2015·Gastroenterology Research and Practice·Alejandra de Moreno de LeBlancJean Guy LeBlanc
Jun 15, 2007·The American Journal of Gastroenterology·Steven J Brown, Lloyd Mayer
Apr 25, 2012·Advanced Materials·Stephen C Balmert, Steven R Little
Jul 12, 2017·World Journal of Gastroenterology : WJG·Chiara DianzaniLoredana Serpe
Apr 23, 2020·Immunological Investigations·Nejat K Egilmez
Mar 21, 2020·Current Topics in Medicinal Chemistry·Prasad MinakshiPreeti Lakhani
Oct 9, 2004·Inflammatory Bowel Diseases·Matthieu Allez, Lloyd Mayer
Nov 4, 2015·World Journal of Gastroenterology : WJG·Hidetoshi TakedatsuTakuji Torimura
Sep 29, 2019·Inflammatory Bowel Diseases·Fanny GironBincy P Abraham
Jul 3, 2010·Expert Review of Clinical Immunology·Arik DahanEllen M Zimmermann
Mar 3, 2004·World Journal of Gastroenterology : WJG·Ming-Cai Li, Shao-Heng He
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Andrea Jaquins-Gerstl, Adrian C Michael
Jan 19, 2005·Journal of Pharmacological Sciences·Kazuyoshi Tomita, Susumu Okabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.