New cytotoxic cyclic peptides and dianthramide from Dianthus superbus

Journal of Natural Products
Pei-Wen HsiehYang-Chang Wu

Abstract

Four new cyclic peptides, dianthins C-F (1-4), and a new dianthramide, 4-methoxydianthramide B (5), were isolated from the MeOH extract of the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1-4 were elucidated as cyclo(Gly(1)-Pro(2)-Phe(3)-Tyr(4)-Val(5)-Ile(6)-), cyclo(Gly(1)-Ser(2)-Leu(3)-Pro(4)-Pro(5)-Ile(6)-Phe(7)-), cyclo(Gly(1)-Pro(2)-Ile(3)-Ser(4)-Phe(5)-Val(6)-), and cyclo(Gly(1)-Pro(2)-Phe(3)-Val(4)-Phe(5)-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. The conformation of compound 1 was established as an alpha-helix by CD analysis. Furthermore, compounds 3 and 5 showed cytotoxicities toward the Hep G2 cancer cell line with IC(50) values of 2.37 and 4.08, respectively.

References

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Citations

Jan 29, 2013·Natural Product Research·Chengli DingJianqing Yu
Mar 4, 2005·Chemical & Pharmaceutical Bulletin·Pei-Wen HsiehYang-Chang Wu
Mar 31, 2015·BioMed Research International·Jaquelina Julia Guzmán-RodríguezJoel E López-Meza
Jul 14, 2011·Proteomics·Hosein MohimaniPavel A Pevzner
Apr 15, 2015·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jing HanNinghua Tan
Apr 16, 2016·Journal of Natural Products·Pâmela J Dos S BeirigoVirgínia C da Silva
Dec 19, 2013·TheScientificWorldJournal·Thiago Lustosa JucáAna Cristina de Oliveira Monteiro-Moreira
Jul 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Enkhtaivan GansukhDoo Hwan Kim
Jun 8, 2017·Natural Product Research·Kiymet MutluSuheyla Kirmizigul
Oct 12, 2017·Environmental Science and Pollution Research International·Xiaoyu YangJianheng Li
Apr 3, 2014·Chembiochem : a European Journal of Chemical Biology·Jutta NiggemannMarkus Kalesse
Jan 29, 2019·Current Topics in Medicinal Chemistry·Shams AaghazAhmed Kamal
Aug 24, 2018·Marine Drugs·Alyaa Hatem IbrahimUsama Ramadan Abdelmohsen
Jan 17, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chung-Yin LinDar-Fu Tai
Feb 2, 2021·Frontiers in Endocrinology·Mohammad Hassan Houshdar TehraniBi Bi Fatemeh Mirjalili
Jan 8, 2008·Journal of Natural Products·George R PettitJean-Charles Chapuis
Jun 26, 2008·Journal of Natural Products·Maryan Bruzual De AbreuAlessandra Braca
May 1, 2021·International Journal of Molecular Sciences·Jia-Nan ZhangHong-Jie Zhang
Mar 9, 2006·Chemical Reviews·Ning-Hua Tan, Jun Zhou

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