New cytotoxic lignan glycosides from Phyllanthus glaucus.

Natural Product Research
Shan YuYing-Jun Zhang

Abstract

During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-α-L-arabinopyranosyl-(1 → 3)-α-L-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-α-L-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Müll. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3-21), four phenylpropanoids (22-25), seven simple phenolics (26-32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 ± 0.2, 19.2 ± 1.7 and 20.5 ± 0.9, respectively.

References

Nov 23, 2000·Journal of Natural Products·Y J ZhangI Kouno
Jul 28, 2001·Journal of Natural Products·Y J ZhangI Kouno
Jan 5, 2002·Journal of Natural Products·Y J ZhangI Kouno
Jul 25, 2003·Phytochemistry·Chia-Chuan ChangShoei-Sheng Lee
Apr 30, 2013·Journal of Natural Products·Jun-Jiang LvYing-Jun Zhang

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Citations

Jan 24, 2017·Natural Product Research·He YanJun Tao Feng
Jul 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hye ParkHyun-Dong Paik

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Methods Mentioned

BETA
column chromatography
NMR

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