New derivatization method for determination of 3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone in water

Journal of Chromatography. a
J NawrockiH Jeleń

Abstract

An extremely potent mutagen, 3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is commonly present in chlorinated drinking water. Due to its high mutagenic activity and according to World Health Organization guidelines its concentration should be controlled in drinking waters. Determination of MX is difficult due to ppt levels at which the compound usually exists in drinking waters. Derivatization of MX with 2-propanol is presented as a method which significantly lowers the GC-MS detection level compared to other alcohol derivatization agents.

Citations

Sep 18, 2003·Chemosphere·T MyllykangasT Vartiainen
Apr 22, 2004·European Journal of Mass Spectrometry·John M Halket, Vladimir V Zaikin
Nov 18, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Thomas A McDonald, Hannu Komulainen
Jun 29, 1999·Analytical Chemistry·S D Richardson

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