PMID: 19122269Jan 6, 2009Paper

New development in bisphosphonate treatment. Bisphosphonates and gastrointestinal adverse effects

Clinical calcium
Takami Miki, Hideki Masaki

Abstract

Endoscopic examination suggested gastric mucosal damage by NSAID is more serious than that of bisphosphonates. In addition, the incidence of GI-adverse effects (AEs) is reported to be insignificant, if the incidence is adjusted by history of peptic ulcer, drugs for comorbidity, sex, age and/or ways of evaluation of the AEs. The anxiety for taking medication under empty stomach may contribute to the increase of GI-AEs. Some consideration must be taken for patients with past history of peptic ulcer, and/or drug user such as NSAIDs.

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