New developmental insights from high-throughput biological analysis in Caenorhabditis elegans

Clinical Genetics
J-C Labbé, R Roy

Abstract

The use of Caenorhabditis elegans as a model system for understanding animal development and human disease has long been recognized as an efficient tool of discovery. Recent developments, particularly in our understanding of RNA-mediated interference and its ability to modify gene activity, have facilitated the use of C. elegans in determining gene function via high-throughput analysis. These new strategies have provided a framework that allows investigators to analyse gene function globally at the genomic level and will likely become a prototypic model for biological analysis in the post-genome era.

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Citations

Apr 24, 2012·Nature Methods·Carolina WählbyAnne E Carpenter
Jun 26, 2015·Nature Communications·Andrew R BurnsPeter J Roy

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