PMID: 9542455May 23, 1998Paper

New developments in asthma therapy: how do individual leukotriene antagonists work?

Praxis
M Wagener

Abstract

Today it is generally acknowledged that bronchial asthma is a chronic inflammatory airway disease which is marked by recurrent bronchial obstructions and hyperreactivity of the airways. The best anti-inflammatory characteristics are shown by corticosteroids. However these can have considerable side-effects in long-term, systemic use. The search for alternative forms of therapy has for some time concentrated on the development and testing of leukotriene antagonists. These can limit the effect of leukotrienes via receptor antagonism or synthesis inhibition. The leukotrienes B4, C4, and D4 count as important key mediators in bronchial asthma. They are released by numerous inflammatory cells, have a bronchoconstricting effect and chemotactic characteristics, promote vessel permeability and increase mucous secretion. In addition, they probably increase bronchial hyperreactivity. Among biosynthesis restrictors, the 5-lipoxygenase restrictors have shown an anti-inflammatory effect in both experimental asthma models and in clinical use. In mild to moderate asthma, lung function improved and the use of a concomitant beta-agonist medication was reduced. While the older leukotriene receptor antagonists were rather disappointing, the newer...Continue Reading

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