New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.

Journal of Thoracic Imaging
Joseph G MammarappallilBastiaan Driehuys

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary disease that is ultimately fatal. Although the diagnosis of IPF has been revolutionized by high-resolution computed tomography, this imaging modality still exhibits significant limitations, particularly in assessing disease progression and therapy response. The need for noninvasive regional assessment has become more acute in light of recently introduced novel therapies and numerous others in the pipeline. Thus, it will likely be valuable to complement 3-dimensional imaging of lung structure with 3-dimensional regional assessment of function. This challenge is well addressed by hyperpolarized (HP) Xe magnetic resonance imaging (MRI), exploiting the unique properties of this inert gas to image its distribution, not only in the airspaces, but also in the interstitial barrier tissues and red blood cells. This single-breath imaging exam could ultimately become the ideal, noninvasive tool to assess pulmonary gas-exchange impairment in IPF. This review article will detail the evolution of HP Xe MRI from its early development to its current state as a clinical research platform. It will detail the key imaging biomarkers that can be generated from the Xe MRI examination, as...Continue Reading

References

Feb 1, 1991·The American Review of Respiratory Disease·A G AgustíR Rodriguez-Roisin
Aug 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R Y ChenS Chien
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·H O CoxsonG W Hunninghake
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Harold R CollardKevin K Brown
Oct 6, 2005·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P)
Jul 1, 2006·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuGerry Oster
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan DriehuysG Allan Johnson
May 20, 2008·Academic Radiology·Samuel PatzJames P Butler
Sep 3, 2010·PloS One·Zackary I ClevelandBastiaan Driehuys
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Brett LeyTalmadge E King
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·John P MuglerKai Ruppert
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
May 17, 2011·Lancet·Paul W NobleUNKNOWN CAPACITY Study Group
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman
Sep 24, 2011·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisAthol U Wells
Feb 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaojun XuJim M Wild
Aug 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeffrey Tsao, Yun Jiang
Nov 8, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Isabel DregelyF William Hersman
Dec 6, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M JohnsonScott Nagle
Jan 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexei OuriadovGiles E Santyr
Apr 9, 2013·The European Respiratory Journal·Fabien MaldonadoJay H Ryu
Apr 17, 2013·Journal of Magnetic Resonance Imaging : JMRI·Sarah SvenningsenGrace Parraga
May 18, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kun QingJohn P Mugler
Aug 21, 2013·Thorax·Sarah SvenningsenGrace Parraga
Jan 8, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·General LeungJim M Wild
May 13, 2014·NMR in Biomedicine·Zackary I ClevelandBastiaan Driehuys
May 20, 2014·The New England Journal of Medicine·Luca RicheldiUNKNOWN INPULSIS Trial Investigators
May 20, 2014·The New England Journal of Medicine·Talmadge E KingUNKNOWN ASCEND Study Group
Aug 1, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Madhwesha RaoJim M Wild

❮ Previous
Next ❯

Citations

Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Andreas Voskrebenzev, Jens Vogel-Claussen
Apr 27, 2019·Current Rheumatology Reports·Sydney B Montesi, Peter Caravan
Sep 15, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam MaunderJim M Wild
Oct 18, 2019·The European Respiratory Journal·Ziyi WangSudarshan Rajagopal
Sep 6, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Vivien SomogyiMichael Kreuter
Dec 8, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Faraz AmzajerdianRahim R Rizi
Jan 6, 2021·Journal of Clinical Medicine·Irma Mahmutovic Persson On Behalf Of The Tristan Consortium
Jul 1, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jordan D FlissGiles Santyr
Jul 18, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vira GrynkoMitchell S Albert
Sep 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiJason C Woods
Jul 7, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nicholas J TustisonJaime F Mata
Nov 4, 2021·NMR in Biomedicine·Abdullah S BdaiwiZackary I Cleveland

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
imaging technique
NMR
gas exchange spectroscopy
biopsies
surgical resection
saturation

Software Mentioned

IDEAL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Inflammation & Allergy Drug Targets
Joseph M ParkerLynne A Murray
Clinical Reviews in Allergy & Immunology
Andrea T BorchersM Eric Gershwin
© 2022 Meta ULC. All rights reserved