New developments in lung function measurements in rodents

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Heinz-Gerd Hoymann

Abstract

There are invasive and noninvasive pulmonary function tests available which are sensitive in detecting bronchoconstriction in rodents. Noninvasively measured midexpiratory flow (EF50) has been shown to be an appropriate parameter to monitor bronchoconstriction in a large number of animals, e.g. for screening purposes. Recently, a novel technique for repetitive lung function measurements in orotracheally intubated, spontaneously breathing mice has been established. Bronchoconstriction is assessed by the "gold standard" parameters airway resistance and dynamic compliance in response to aerosolized methacholine or allergens in anesthetized mice. This measurement technique has been combined with an inhalation technique which has been optimized to allow simultaneous lung function measurement in intubated animals and to obtain high aerosol concentrations. A feedback dose control system has been developed to administer a defined and constant aerosol dose to each individual animal. Using this system a prominent early allergic response and late airway hyperresponsiveness could be demonstrated in intubated mice challenged with Aspergillus fumigatus allergen. We conclude: The noninvasive EF50 method seems particularly appropriate for meas...Continue Reading

References

Sep 1, 1967·Archives of Environmental Health·F PalecekD M Aviado
Jun 1, 1982·Respiration Physiology·A C Jackson, J W Watson
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Feb 25, 2000·International Archives of Allergy and Immunology·U Neuhaus-SteinmetzH Renz
Sep 18, 2002·Journal of Applied Physiology·Lennart K A LundbladJason H T Bates
Sep 18, 2002·Journal of Applied Physiology·Thomas GlaabHelmut Fabel
Jan 18, 2003·Journal of Applied Physiology·Wayne Mitzner, Clarke Tankersley

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Citations

Apr 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Natalie J SerkovaKathleen A Stringer
Apr 7, 2009·American Journal of Respiratory Cell and Molecular Biology·Jeroen A J VanoirbeekWim Janssens
Apr 12, 2008·Journal of Translational Medicine·Kjetil AskMartin R J Kolb
Apr 5, 2011·The Journal of Allergy and Clinical Immunology·Melanie AlbrechtAnna-Maria Dittrich
Jan 5, 2011·Pulmonary Pharmacology & Therapeutics·Matthias J DuechsKlaus J Erb
Mar 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M NassimiC Müller-Goymann
Feb 12, 2010·European Journal of Immunology·Christina HartwigGeorg M N Behrens
Apr 6, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Armin Braun, Thomas Tschernig
Jun 24, 2006·Journal of Pharmacological and Toxicological Methods·Heinz Gerd Hoymann
Jul 5, 2013·Clinical Science·Sabine RochlitzerUNKNOWN U-BIOPRED consortium
Jun 27, 2015·PloS One·Vineet D MenacheryMartin T Ferris
Mar 2, 2011·Laboratory Animals·Stéphanie I De VleeschauwerWim Janssens
Feb 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Annette RobichaudThomas F Schuessler
Sep 16, 2019·Respiratory Research·Eline BonnardelIsabelle Dupin
Apr 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Milena J TosiekDunja Bruder

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