New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV

European Journal of Medicinal Chemistry
Syed Lal Badshah, Asad Ullah

Abstract

The inhibition of pathogenic bacteria at the replication stage is important to halt their further reproduction and spread. The replication enzymes include the DNA gyrase and topoisomerase IV that are recognized targets for the infection control. Novel antibiotic compounds are always in demand for targeting different active sites of these enzymes. Although quinolones are the current drug of choice for targeting these enzymes, emerging resistance is a global concern. Wide-scale efforts are needed to overcome the emerging resistance by designing more potent drugs. In this article, we have reviewed the last five years progress of various classes of non-quinolone-based chemical compounds that are tested for their antibacterial activities.

Citations

Nov 14, 2019·ChemMedChem·Benedetta FoisDanijel Kikelj
Jul 16, 2020·Archiv der Pharmazie·Feng SongMeng Zhou
Oct 18, 2019·Chemical Biology & Drug Design·Israa A SeliemZakaria K M Abdel-Samii
Mar 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Shuai YangDan-Qing Song
Jan 29, 2019·Expert Opinion on Therapeutic Patents·Martina DurcikJanez Ilaš
Feb 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahSyed Lal Badshah
Feb 7, 2021·Journal of Molecular Modeling·Luiz F N NavesHamilton B Napolitano
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahMariusz Jaremko
Jul 14, 2021·The Journal of Antibiotics·Oxana KazakovaDmitry Baev

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