New developments in skin replacement materials

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
M PrzybilskiG Germann

Abstract

Current treatment strategies in intensive care medicine permit survival of patients with burns of more than 80% of the total body surface area (TBSA). Major burns result in extensive skin defects. Thus, burn victims often suffer from scar contractures, altered thermoregulation, and unsatisfactory cosmetic results. In addition to the well-established cultivated epithelial autografts, a number of new composite grafts have been developed in the field of tissue engineering. The combination of synthetic and allogenic matrix structures together with an allogenic or autologous epithelium allows the possibility of mimicking skin structure. The aim is to achieve improved wound healing by regeneration of dermal tissue instead of scarring. This article provides an overview of the currently available products which have already been introduced into clinical routine as well as describing advantages and disadvantages of the individual products and their indications.

Citations

Mar 5, 2005·Der Unfallchirurg·K PhilippM Sauerbier
Aug 20, 2011·Burns : Journal of the International Society for Burn Injuries·Afshin Rahmanian-SchwarzOliver Lotter
Nov 16, 2010·Burns : Journal of the International Society for Burn Injuries·C A RaduH Ryssel
May 12, 2007·Burns : Journal of the International Society for Burn Injuries·H SchwarzeB Hartmann
Nov 7, 2006·Burns : Journal of the International Society for Burn Injuries·C UhligK-K Dittel
Feb 20, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Doris Maria KimMartin Klein
Apr 29, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Dan BielerGerhard Achatz

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