New developments in the comprehension of the biotransformation and transport of insulin-enhancing vanadium compounds in the blood serum

Inorganic Chemistry
Daniele SannaEugenio Garribba

Abstract

The possible biotransformations in the blood serum of four representative insulin-enhancing vanadium compounds, [VO(6-mepic)(2)], cis-[VO(pic)(2)(H(2)O)], [VO(acac)(2)], and [VO(dhp)(2)], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic and picolinic acids, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, were examined. In particular, the behavior of the quinary systems formed by the insulin-enhancing species, human serum apo-transferrin (hTf), human serum albumin (HSA), and lactate (lact) or citrate (citr) at physiological pH and conditions was studied. The results indicate that, besides the case in which the ligand is very weak like 6-mepic, the carrier can interact in some form with VO(2+) ion until its intake into the cell. In fact with stronger ligands like pic, acac, and dhp, VO(2+) is transported not only by transferrin but also as [VO(carrier)(2)] and as mixed species VO(2+)-hTF-carrier. There are two ways in which the undissociated form of a bis-chelated complex can interact with transferrin, one "specific" when the carrier possesses a carboxylate group and behaves like a synergistic anion, and another "non-specific" when an imidazole nitrogen of a histidine residue from...Continue Reading

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Jun 12, 2009·Inorganic Chemistry·Daniele SannaEugenio Garribba

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Citations

Mar 26, 2011·Inorganic Chemistry·Daniele SannaEugenio Garribba
Oct 5, 2013·Inorganic Chemistry·Daniele SannaEugenio Garribba
Mar 27, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniele SannaEugenio Garribba
Apr 25, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniele SannaEugenio Garribba
Aug 21, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gonçalo C JustinoJoão Costa Pessoa
Sep 26, 2015·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·I E LeónS B Etcheverry
Jul 26, 2011·Biochimica Et Biophysica Acta·John B Vincent, Sharifa Love
Oct 4, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ignacio E LeónSusana B Etcheverry
Apr 13, 2017·Chemistry, an Asian Journal·Aviva Levina, Peter A Lay
Jun 24, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba
Jun 27, 2017·Chemistry, an Asian Journal·Isabel CorreiaJoão Costa Pessoa
Jul 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Aviva Levina, Peter A Lay
Apr 6, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Isabel CorreiaTamás Kiss
May 12, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba
May 10, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Peter W WinterDebbie C Crans
Aug 29, 2013·Metallomics : Integrated Biometal Science·Gail R WillskyPaul J Kostyniak
Mar 29, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Yutaka YoshikawaEugenio Garribba
Nov 19, 2011·Metallomics : Integrated Biometal Science·Daniele SannaEugenio Garribba
May 22, 2020·Chemistry : a European Journal·Eugenio GarribbaJean-Didier Maréchal
Sep 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba
May 17, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Gisela GonçalvesJoão Costa Pessoa
Jul 31, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Elzbieta Lodyga-ChruscinskaEugenio Garribba
Jan 13, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba
Dec 24, 2018·Journal of Medicinal Chemistry·Daniele SannaEugenio Garribba
Apr 4, 2018·Inorganic Chemistry·Giuseppe SciortinoEugenio Garribba
Nov 5, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniele SannaEugenio Garribba

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