PMID: 7544479Jan 1, 1995Paper

New diagnostic applications and physiological functions of prostate specific antigen

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
Eleftherios P Diamandis

Abstract

Prostate specific antigen was, until recently, thought to be a highly specific biochemical marker of prostatic epithelial cells. Using highly sensitive techniques, we have recently found that PSA is present in 30-40% of breast tumors and at a lower percentage in other tumors including lung, colon, ovary, liver, kidney, adrenal and parotid tumors. Others have found PSA in skin and salivary gland tumors and in normal endometrium. We found PSA in normal breast, milk of lactating women and in amniotic fluid. The physiological role of PSA in these tissues and tumors is currently unknown. It appears that PSA is either a growth factor or a growth factor regulator and that it may play a role in fetal development. A substrate for PSA in these tissues has not as yet been identified.

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Citations

Feb 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·M VoglW Höltl
Jul 1, 1998·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·K Meyer-SieglerP B Hudson
Oct 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Bakheet ElsadekFelix Kratz
May 25, 2005·Cancer Letters·Christina V Obiezu, Eleftherios P Diamandis
Dec 23, 2014·Medicinal Research Reviews·Herve Aloysius, Longqin Hu
Apr 1, 2005·Neoplasia : an International Journal for Oncology Research·B BindukumarKailash C Chadha
Aug 28, 2007·Chemical Biology & Drug Design·Md Imtaiyaz HassanSavita Yadav
Jan 6, 1997·International Journal of Cancer. Journal International Du Cancer·W HenkeS A Loening
Aug 12, 2010·ACS Medicinal Chemistry Letters·Bakheet ElsadekFelix Kratz

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