PMID: 11908966Mar 23, 2002Paper

New diarylheptanoids and diarylheptanoid glucosides from the rhizomes of Tacca chantrieri and their cytotoxic activity

Journal of Natural Products
Akihito YokosukaYutaka Sashida

Abstract

Two new diarylheptanoids (1, 2) and seven new diarylheptanoid glucosides (3-9) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage. The absolute configurations of the 3,5-dihydroxyheptane moieties of the new diarylheptanoids were determined to be 3R and 5R by the application of the CD exciton chirality method to the corresponding 3,5-bis-p-bromobenzoyl derivatives. The cytotoxic activities of the isolated compounds and some derivatives against HL-60 human promyelocytic leukemia cells, HSC-2 human oral squamous carcinoma cells, and normal human gingival fibroblasts (HGF) are reported.

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Citations

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Aug 19, 2010·Journal of Natural Products·Jiangnan PengSusan L Mooberry
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Dec 7, 2013·Journal of Natural Products·Jiangnan PengSusan L Mooberry
May 10, 2007·Natural Product Research·Wimal HerathIkhlas A Khan
Nov 2, 2004·Chemical & Pharmaceutical Bulletin·Akihito YokosukaYutaka Sashida
Jul 5, 2006·Chemical & Pharmaceutical Bulletin·Hai-Yang LiuChang-Xiang Chen
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Oct 11, 2014·Journal of Natural Medicines·Takahiro MatsumotoHisashi Matsuda
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Jun 18, 2016·Phytochemical Analysis : PCA·Vivian T DikeAlexander I Gray
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Aug 16, 2018·Phytotherapy Research : PTR·Pattreeya TungcharoenSupinya Tewtrakul
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Mar 17, 2010·Chemistry & Biodiversity·Htay Htay ShweJörg Heilmann
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May 25, 2021·Journal of Agricultural and Food Chemistry·Pei-Feng ZhuXiao-Dong Luo

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