New Digital Plug and Imaging Sensor for a Proton Therapy Monitoring System Based on Positron Emission Tomography

Sensors
Nicola D'AscenzoQingguo Xie

Abstract

One of the most challenging areas of sensor development for nuclear medicine is the design of proton therapy monitoring systems. Sensors are operated in a high detection rate regime in beam-on conditions. We realized a prototype of a monitoring system for proton therapy based on the technique of positron emission tomography. We used the Plug and Imaging (P&I) technology in this application. This sensing system includes LYSO/silicon photomultiplier (SiPM) detection elements, fast digital multi voltage threshold (MVT) readout electronics and dedicated image reconstruction algorithms. In this paper, we show that the P&I sensor system has a uniform response and is controllable in the experimental conditions of the proton therapy room. The prototype of PET monitoring device based on the P&I sensor system has an intrinsic experimental spatial resolution of approximately 3 mm (FWHM), obtained operating the prototype both during the beam irradiation and right after it. The count-rate performance of the P&I sensor approaches 5 Mcps and allows the collection of relevant statistics for the nuclide analysis. The measurement of both the half life and the relative abundance of the positron emitters generated in the target vol...Continue Reading

References

Jan 1, 1996·Physics in Medicine and Biology·U OelfkeM S Atkins
Dec 1, 2000·Physics in Medicine and Biology·K Parodi, W Enghardt
Jan 30, 2002·Physics in Medicine and Biology·K ParodiT Haberer
Apr 6, 2006·Physics in Medicine and Biology·Katia Parodi, Thomas Bortfeld
Apr 21, 2006·Physics in Medicine and Biology·Paulo CrespoWolfgang Enghardt
Nov 22, 2007·Physics in Medicine and Biology·Paulo CrespoAndreas Wagner
Aug 15, 2008·Physics in Medicine and Biology·Harald PaganettiMartijn Engelsman
Nov 13, 2008·Physics in Medicine and Biology·Sascha MoehrsGianluigi Zanetti
Aug 20, 2009·Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment·H KimW S Choong
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Teiji NishioHiroyasu Esumi
Apr 9, 2010·IEEE Transactions on Nuclear Science·Qingguo XieChin-Tu Chen
Jul 22, 2010·International Journal of Radiation Oncology, Biology, Physics·Antje-Christin KnopfHelen Shih
Jun 17, 2011·Physics in Medicine and Biology·Xuping ZhuGeorges El Fakhri
May 11, 2012·Physics in Medicine and Biology·Harald Paganetti
May 11, 2012·Physics in Medicine and Biology·J SmeetsA Dubus
Jul 4, 2012·Physics in Medicine and Biology·Hideaki TashimaEiichi Tanaka
Feb 9, 2013·International Journal of Radiation Oncology, Biology, Physics·Chul Hee MinHelen A Shih
May 22, 2013·Nature Reviews. Clinical Oncology·Jay S Loeffler, Marco Durante
Oct 23, 2013·Physics in Medicine and Biology·Zhenzhou DengPeng Xiao
Dec 11, 2013·Physics in Medicine and Biology·G SportelliV Rosso
Dec 6, 2014·Annals of Nuclear Medicine·Seiichi YamamotoShu Fujimaki
Nov 6, 2015·Physics in Medicine and Biology·P DendoovenS Brandenburg
Aug 2, 2016·Physics in Medicine and Biology·P Cambraia LopesD R Schaart
Aug 24, 2016·Zeitschrift für medizinische Physik·Stephan HelmbrechtThomas Kormoll
Nov 8, 2016·Physics in Medicine and Biology·M A PilieroR Wheadon
Dec 27, 2016·Journal of Medical Imaging·Daoming XiQingguo Xie
Apr 6, 2017·Physics in Medicine and Biology·H J T BuitenhuisP Dendooven
Sep 28, 2017·Sensors·Nicola D'AscenzoQingguo Xie

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Software Mentioned

GEANT4
TALYS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.