New dimeric members of the phomoxanthone family: phomolactonexanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp

Marine Drugs
Bo DingZhigang She

Abstract

Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 1-3 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cytotoxic activities against tested cancer cell lines (IC₅₀ < 10 μM).

References

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Citations

Nov 7, 2015·Journal of the American Chemical Society·Tian QinJohn A Porco
Oct 1, 2016·Natural Product Research·Runlin CaiZhigang She
Sep 17, 2014·Natural Product Reports·Tim WezemanKye-Simeon Masters
Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 6, 2017·Journal of Asian Natural Products Research·Pan WangJun Wu
May 17, 2018·Journal of Natural Products·Chun GuiJianhua Ju
Sep 21, 2021·Journal of Agricultural and Food Chemistry·Xiaoping PengHongxiang Lou
Sep 21, 2021·Frontiers in Microbiology·Jucélia IantasChirlei Glienke
Oct 9, 2021·Natural Product Reports·Senhua ChenZhigang She

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Methods Mentioned

BETA
NMR
column chromatography

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