New dinuclear palladium(II) complexes with benzodiazines as bridging ligands: interactions with CT-DNA and BSA, and cytotoxic activity

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Andjela A FranichSnežana Rajković

Abstract

Three new dinuclear Pd(II) complexes with general formula [{Pd(en)Cl}2(μ-L)](NO3)2 [L is bridging ligand quinoxaline (Pd1), quinazoline (Pd2) and phthalazine (Pd3)] were synthesized and characterized by elemental microanalyses, UV-Vis, IR and NMR (1H and 13C) spectroscopy. The interaction of dinuclear Pd1-Pd3 complexes with calf thymus DNA (CT-DNA) has been monitored by viscosity measurements, UV-Vis and fluorescence emission spectroscopy in aqueous phosphate buffer solution (PBS) at pH 7.40 and 37 °C. In addition, these experimental conditions have been applied to investigate the binding affinities of Pd1-Pd3 complexes to the bovine serum albumin (BSA) by fluorescence emission spectroscopy. In vitro antiproliferative and apoptotic activities of the dinuclear Pd(II) complexes have been tested on colorectal and lung cancer cell lines. All tested Pd(II) complexes had lower cytotoxic effect than cisplatin against colorectal cancer cells, but also had similar or even higher cytotoxicity than cisplatin against lung cancer cells. All complexes induced apoptosis of colorectal and lung cancer cells, while the highest antiproliferative effect exerted Pd2 complex.

References

Oct 10, 2002·British Journal of Cancer·J Cosaert, E Quoix
Mar 21, 2003·Journal of Medicinal Chemistry·Seiji KomedaJan Reedijk
Apr 30, 2003·Cell Death and Differentiation·M Oren
Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura J van 't Veer
Jan 18, 2006·Journal of Pharmaceutical and Biomedical Analysis·P B KandagalO B Ijare
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Dec 15, 2006·Journal of the American Chemical Society·Seiji KomedaLoren Dean Williams
Nov 3, 2009·European Journal of Medicinal Chemistry·Gopal SathyarajBalachandran Unni Nair
Nov 21, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xin Lin WeiYalong Bai
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Apr 12, 2014·Chemical Society Reviews·Anant R Kapdi, Ian J S Fairlamb
Jan 1, 2011·Journal of Surgical Case Reports·A SugamataN Yoshizawa
Dec 3, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zahra JannesariBatool Maleki
Jan 13, 2016·CA: a Cancer Journal for Clinicians·Mary Kay Barton
Jul 20, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Snežana JovanovićBiljana Petrović
Dec 7, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Magdalena Makarska-Bialokoz
Sep 14, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·SneŽana RadisavljevićAna Rilak Simović
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mixo Aunny SibiyaThabe Moses Matsebatlela

❮ Previous
Next ❯

Citations

Dec 3, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehran Feizi-DehnayebiHassan Mansouri-Torshizi
May 25, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Reinner O OmondiStephen O Ojwach
Aug 8, 2021·International Journal of Molecular Sciences·Robert CzarnomysyKrzysztof Bielawski

❮ Previous
Next ❯

Methods Mentioned

BETA
FACS
NMR
viscosity titration
Fluorescence
flow cytometry

Software Mentioned

FlowJo Star
FlowJo
SPSS

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis