New discriminant score to predict the fibrotic stage of non-alcoholic steatohepatitis in Japan

Hepatology International
Yusuke KawamuraHiromitsu Kumada

Abstract

Currently, non-alcoholic steatohepatitis (NASH) can only be diagnosed histopathologically. Our objective was to establish a new scoring system for the fibrotic stage of NASH. We enrolled 139 patients with histologically proven NASH and divided them into two groups to construct (n = 90) and validate (n = 49) a fibrotic score for NASH (FSN). We used 17 variables and their natural logarithmic transformations in the multivariate analysis. To assess the accuracy of the FSN in determining NASH advanced fibrosis (stages 3-4), we compared various fibrotic scores for NASH. In the construct group, multivariate regression analysis ultimately obtained the following function: z = 1.022 × ln (type IV collagen 7S) (ng/mL) - 0.00680 × (platelet count) (×10(9)/L) + 1.925 × ln (AST) (IU/L) - 1.239 × ln (ALT) (IU/L) + 0.249. Median values of the FSN for stages 1, 2, 3 and 4 were 1.87, 2.14, 3.26 and 3.89, respectively. The multiple regression coefficient and coefficient of determination were 0.70 and 0.46, respectively. In the validation group, the median value was 2.00, 2.83, 3.08 and 4.37 in each stage. With regard to the utility of the FSN for predicting advanced fibrosis of NASH (stage ≥3), the area under the receiver operating characteristic...Continue Reading

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Citations

Apr 21, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuichiro EguchiYoshio Sumida
Jan 3, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Takefumi KimuraTakeji Umemura
Jun 25, 2021·World Journal of Gastroenterology : WJG·Tasur Kumar SeenRaghav Bansal
Sep 18, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Katsutoshi TokushigeKazuhiko Koike
Sep 18, 2021·Journal of Gastroenterology·Katsutoshi TokushigeKazuhiko Koike

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
surgical resection
biopsies

Software Mentioned

SPSS

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