PMID: 11604597Oct 18, 2001Paper

New drug therapies for the pediatric rheumatic diseases

Current Opinion in Rheumatology
B J Bloom

Abstract

Such developments as the introduction of whole new drug classes, as well as the general increase in pediatric drug trials, have led to a revolution in pediatric rheumatology care. For example, selective cyclooxygenase-2 inhibitors can provide the same symptomatic relief as nonselective nonsteroidal anti-inflammatory agents without the same concerns over significant gastrointestinal toxicity. Biologic agents, notably the tumor necrosis factor inhibitors, have effected dramatic improvements in many patients with severe disease who previously were often significantly disabled. New immunosuppressives, such as mycophenolate mofetil, also have promise for ameliorating systemic lupus and vasculitic conditions, perhaps with reduced toxicity compared with other agents. New strategies for the use of older agents have also been further substantiated, such as intra-articular steroid and alternate-day high-dose steroid in chronic arthritis, and broader use of sulfasalazine. Evidence for the use of these therapies is discussed, as are potential toxicities.

References

Jun 23, 1999·Rheumatology·P P TakF C Breedveld
Oct 16, 1999·Annals of Internal Medicine·P H BrionK C Kalunian
Feb 23, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E Jacqz-AigrainC Loirat
Mar 1, 2000·Archives of Internal Medicine·R Carrillo-Jimenez, M Nurnberger
Apr 15, 2000·Annals of Internal Medicine·A M BaciewiczT J King
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A Perazella, J Eras
Aug 5, 2000·The American Journal of Gastroenterology·J L GoldsteinG S Geis
Sep 9, 2000·Annals of Internal Medicine·G WolfR A Stahl
Feb 22, 2002·Arthritis and Rheumatism·William P. Arend

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Citations

Aug 2, 2003·Holistic Nursing Practice·Susan E LabyakSharron Docherty
Feb 3, 2005·Orthopedics·David E Rojer, Stuart B Goodman
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Rayfel Schneider, Murray H Passo

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