New drugs and technologies, intravenous anaesthesia is on the move (again)

British Journal of Anaesthesia
J R Sneyd, A E Rigby-Jones

Abstract

Although well established in clinical practice, both propofol and midazolam have limitations. New hypnotics with different and potentially superior pharmacokinetics and pharmacodynamics are under development. These include the benzodiazepine receptor agonists CNS7056 and JM-1232 (-), the etomidate-based methoxycarbonyl-etomidate and carboetomidate, the propofol-related structures PF0713 and fospropofol, and THRX-918661/AZD3043. The basic pharmacology and the initial anaesthesia studies for each of these agents are reviewed. Several of the agents (CNS7056, THRX-918661/AZD3043, and fospropofol) have reached the stage of clinical trials. To be successful, novel compounds need to establish clear clinical advantages over existing agents and where possible the new agents are discussed in this context. Computer-controlled drug administration offers the ability to automatically implement infusion schemes too complex for manual use and the possibility of linking patient monitoring to administration to enhance patient safety.

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Citations

Oct 12, 2010·British Journal of Anaesthesia·R N UptonC Grant
Jan 22, 2011·Current Opinion in Anaesthesiology·J Robert Sneyd, Katherine A Holmes
Apr 10, 2013·Expert Opinion on Drug Delivery·Robert A Peterfreund, James H Philip
Apr 9, 2015·Scientific Reports·Brian P WeiserRoderic G Eckenhoff
May 31, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Talmage D Egan
Apr 26, 2016·Brazilian Journal of Anesthesiology·José Carlos RittesLigia Andrade da Silva Telles Mathias
Jun 5, 2012·Revista brasileira de anestesiologia·Thiago Alves RodriguesLigia Andrade da Silva Telles Mathias
Jan 7, 2015·Pharmacological Reports : PR·Chao ZhaoAidong Wen
Jan 10, 2017·Expert Opinion on Pharmacotherapy·Kammy Ks Poon, Steven Hs Wong
Apr 22, 2017·Journal of Medicinal Chemistry·Linlin QinYonggang Wei
May 9, 2013·Surgical Neurology International·Hovig V ChitilianDouglas E Raines
May 12, 2016·British Journal of Hospital Medicine·Claire Allen, Stephen Washington
Apr 26, 2019·Current Opinion in Anaesthesiology·Steven D Boggs, Markus M Luedi
Dec 31, 2019·Paediatric Anaesthesia·Gillian R LauderThomas Engelhardt
Mar 22, 2014·Anesthesia and Analgesia·Bing-Chen LangWen-Sheng Zhang
Dec 20, 2011·Critical Care Medicine·William L Jackson
Jul 3, 2015·Current Opinion in Anaesthesiology·Tom G Hansen
Mar 26, 2015·International Anesthesiology Clinics·Jessica A Darnobid
Jun 19, 2015·Current Opinion in Anaesthesiology·Esther R Michel Foehn
Mar 10, 2021·Expert Review of Clinical Pharmacology·Weiyun ChenYuguang Huang
Oct 4, 2019·Current Medicinal Chemistry·Yuzhong WangCheng-Pan Zhang
Nov 22, 2017·British Journal of Anaesthesia·J R Sneyd

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