PMID: 11917722Mar 29, 2002Paper

New drugs for the treatment of functional dyspepsia

Arquivos De Gastroenterologia
L E Troncon

Abstract

Functional dyspepsia is defined by upper gastrointestinal symptoms without any evidence of structural abnormalities or organic disease. Current pharmacological treatment of functional dyspepsia is largely empirical and involves anti-secretory or prokinetic drugs. To review recent advances in the understanding of the mechanisms involved in symptom production in functional dyspepsia, as well as the development of new drugs that may interfere with these mechanisms, which may lead to more rational and effective treatment of this clinical condition. Systematic review of papers published in English for the last 10 years. New drugs that increase propulsive gastroduodenal motor activity include new benzamides similar to cisapride, CCK-A blockers, agonists of opiate receptors and motilin agonists similar to erythromycin. A number of agents, including sumatriptan and buspirone, stimulates serotonin receptors in the myoenteric plexuses and have been shown to increase gastric accommodation to a meal. Finally, a number of new drugs that either increase thresholds for visceral perception or modify sensations is currently under investigation. This includes agents of several groups, such as octreotide, loxiglumide, ondansetron and other seroto...Continue Reading

References

May 1, 1992·Scandinavian Journal of Gastroenterology·T Hausken, A Berstad
May 1, 1985·Gastroenterology·J R Malagelada, V Stanghellini
Apr 1, 1995·Alimentary Pharmacology & Therapeutics·N J Talley
May 1, 1995·Scandinavian Journal of Gastroenterology·M BortolottiL Barbara
Jan 1, 1994·Scandinavian Journal of Gastroenterology·T Hausken, A Berstad
Aug 1, 1996·Alimentary Pharmacology & Therapeutics·D G MaxtonP J Whorwell
Dec 1, 1996·Alimentary Pharmacology & Therapeutics·B CoffinR Jian
Feb 19, 1998·The American Journal of Gastroenterology·H MertzE A Mayer
Mar 24, 1998·Annual Review of Medicine·L Agréus, N J Talley
May 20, 1998·Digestive Diseases and Sciences·A SonnenbergH B El-Serag
Nov 5, 1998·The New England Journal of Medicine·R S Fisher, H P Parkman
Dec 16, 1998·Journal of Gastroenterology·T KamiyaT Fujinami
Aug 24, 1999·Gut·N J TalleyG N Tytgat
Sep 14, 1999·The American Journal of Gastroenterology·Z LinR W McCallum
Jun 27, 2000·Gastroenterology·J E PandolfinoP J Kahrilas

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