PMID: 8601332Apr 1, 1996Paper

New drugs for the treatment of epilepsy

Clinical Biochemistry
A D Fraser

Abstract

This article will review current data on the metabolism, interactions, methods of analysis, and adverse effects observed with the use of new anticonvulsant drugs. The role of the laboratory in the provision of therapeutic drug monitoring for these drugs is discussed. Certain of the newer anticonvulsant drugs require therapeutic drug monitoring for their optimal use in the treatment of epileptic seizures. The requirement for therapeutic drug monitoring has not been established for some of these drugs. Many of the newer anticonvulsant drugs, including lamotrigine, felbamate, vigabatrin, and zonisamide, interact clinically with established drugs, such as phenytoin, phenobarbital, carbamazepine, and valproic acid. Introduction of these new drugs will result in the need for more frequent monitoring of the established drugs during polytherapy. The need for a drug-monitoring service for anticonvulsant drugs overall will continue, due to the frequency of drug interactions, the incidence of adverse effects, and concerns about compliance with the dosing regimen in these patients.

References

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Citations

Jul 6, 2000·Archives of Medical Research·D F González-EsquivelH Jung-Cook
May 15, 2002·Journal of Pharmaceutical and Biomedical Analysis·H LevertH Robert
Oct 2, 2003·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lena K A RätyBirgitta A Söderfeldt
Feb 12, 1998·British Journal of Pharmacology·T IbbotsonP R Boden
Jan 25, 2012·International Journal of Molecular Sciences·Juan C Garro MartinezEduardo A Castro
Jul 26, 2011·International Journal of Analytical Chemistry·Nagaraju RajendraprasadKanakapura B Vinay
Mar 1, 1997·Seminars in Pediatric Neurology·J M Pellock, N Watemberg
Jan 30, 2004·Basic & Clinical Pharmacology & Toxicology·Wolfgang FischerGiovambattista De Sarro
Apr 30, 2002·The Annals of Pharmacotherapy·Elaine Chong, L Lee Dupuis
Apr 16, 2002·Journal of Child Neurology·Tracy A Glauser, John M Pellock
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Dec 1, 2004·Therapeutic Drug Monitoring·Raymond G MorrisAndrew B Black
Jan 24, 2002·Therapeutic Drug Monitoring·Houda HachadRene H Levy
Jun 19, 2013·Chemical Communications : Chem Comm·David StephensOleg V Larionov
May 6, 2021·Acta Neurologica Scandinavica·Irene Aícua-RapúnJan Novy

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