New drugs for treatment of multiple myeloma

The Lancet Oncology
Benedetto BrunoMario Boccadoro

Abstract

Multiple myeloma (MM) is a disease of plasma cells that has fatal consequences. New insights into the biology of MM have identified molecular mechanisms that hold promise as therapeutic targets. Laboratory and preclinical studies have shown that intracellular regulatory proteins and functional interactions between MM cells and the bone-marrow microenvironment have a pivotal role in the growth, survival, drug resistance, and malignant progression of MM cells. New agents associated with molecular targets have prompted clinical investigators to design new treatment strategies initially for advanced MM and later for newly diagnosed MM, with encouraging preliminary results. Here, we discuss the mechanisms of action of these new rational drugs and the preliminary clinical outcomes of a new treatment regimen for MM.

References

Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·B E TurkJ O Liu
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T K SenguptaL B Ivashkiv
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Feb 26, 2000·British Journal of Haematology·A KnellerI Ben-Bassat
Sep 20, 2000·Mayo Clinic Proceedings·S V RajkumarP R Greipp
Sep 30, 2000·The New England Journal of Medicine·S V RajkumarT E Witzig
Mar 21, 2002·The American Journal of Medicine·Ashraf Z BadrosGuido Tricot
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R AlexanianK Delasalle
Aug 30, 2002·Blood·Dharminder ChauhanKenneth C Anderson
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Vincent RajkumarThomas E Witzig
May 7, 2003·The Lancet Oncology·Ambuj KumarBenjamin Djulbegovic

❮ Previous
Next ❯

Citations

Sep 30, 2005·Cancer Immunology, Immunotherapy : CII·F L ZhouS H Liu
Sep 18, 2007·Annals of Hematology·Irfan YavasogluZahit Bolaman
Sep 27, 2008·Apoptosis : an International Journal on Programmed Cell Death·Kalyan J GangavarapuChristopher K Daniels
May 6, 2006·Thyroid : Official Journal of the American Thyroid Association·Pernilla RoswallNils-Erik Heldin
Jun 3, 2005·Cancer Cell International·Mario BoccadoroJamie Cavenagh
Aug 10, 2010·Core Evidence·Paul RichardsonKenneth Anderson
Mar 3, 2007·European Journal of Haematology·Benedetto BrunoUNKNOWN Gruppo Italiano Trapianto Midollo Osseo
Mar 8, 2006·European Journal of Haematology·Antonio PalumboMario Boccadoro
Jun 21, 2013·Fundamental & Clinical Pharmacology·Benjamin HontonAtul Pathak
Jun 7, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Sébastien MaillardJack-Michel Renoir
Jan 12, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Seon Young KimUNKNOWN Korea Multiple Myeloma Working Party
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Klaus PodarKenneth C Anderson
Jun 9, 2009·Journal of Experimental & Clinical Cancer Research : CR·Céline KerrosStéphane Allouche
May 3, 2006·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Murat KaraSalih Aksu
Mar 1, 2006·The Journal of Laboratory and Clinical Medicine·Sándor Eckhardt
Dec 1, 2005·Blood·Gian Matteo RigolinGianluigi Castoldi
Jan 13, 2006·The Oncologist·Jesús San MiguelHeinz Ludwig
Apr 28, 2005·Cancer Control : Journal of the Moffitt Cancer Center·Wee Joo ChngBenjamin M F Mow
Nov 17, 2006·World Journal of Gastroenterology : WJG·Hsueh-Erh ChiouHui-Wen Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis