PMID: 9185705Jun 11, 1997Paper

New EGF-R selective tyrosine kinase inhibitor reveals variable growth responses in prostate carcinoma cell lines PC-3 and DU-145

International Journal of Cancer. Journal International Du Cancer
H E JonesR I Nicholson

Abstract

The effect of an EGF-R selective tyrosine kinase inhibitor ZM252868 was evaluated on the proliferation of PC-3 and DU-145 prostate cancer cell lines, which are purported to utilize an EGF-R-mediated autocrine pathway for regulation of cell growth. Basal growth of DU-145 cells was inhibited in a dose-dependent manner by the inhibitor, showing a 70% reduction at 1 microM, whilst the growth of PC-3 cells was not affected at this concentration. In the presence of 0.1 microM inhibitor, EGF and TGF alpha-stimulated DU-145 cell growth was decreased to below basal levels, while only TGF alpha-stimulated PC-3 cell growth was inhibited at a 1-microM concentration. Any growth responses to aFGF, bFGF, KGF, IGF1 and PDGF by DU-145 and PC-3 cells were unaffected by the inhibitor at concentrations of 1 microM or less. Additionally, the distribution of immunoreactive EGF-R varied between DU-145 and PC-3 cells, with EGF-R being predominately located on the cell membrane and in the cytoplasm, respectively.

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Citations

Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·J M GeeR I Nicholson
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Jul 29, 2004·FEBS Letters·Ximena Montano, Mustafa B A Djamgoz
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Eleanor GutteridgeJulia Gee
May 1, 2012·Journal of Oncology·Yuh BabaYasumasa Kato
Nov 1, 2000·The Prostate. Supplement·K Griffiths, L J Denis
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·J GreshamW J Wasilenko
Jul 4, 2002·Annals of the New York Academy of Sciences·R I NicholsonJ M W Gee
Feb 14, 2002·British Journal of Haematology·Farhad RavandiZeev Estrov
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joan AlbanellJose Baselga
Mar 22, 2002·Biochemical and Biophysical Research Communications·Hong ZhaoRajvir Dahiya
Jun 8, 2002·Biochemical and Biophysical Research Communications·Hong ZhaoRajvir Dahiya

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