New evidence for preserved somatosensory pathways in complete spinal cord injury: A fMRI study

Human Brain Mapping
P J WrigleyS M Gustin

Abstract

Trauma to the spinal cord rarely results in complete division of the cord with surviving nerves sometimes remaining silent or failing to function normally. The term motor or sensory discomplete has been used to describe this important but unclassified subgroup of complete SCI. Importantly, silent motor or sensory pathways may contribute to aversive symptoms (spasticity, pain) or improved treatment success. To demonstrate more objectively the presence of subclinical preserved somatosensory pathways in clinically complete SCI, a cross-sectional study using functional MRI (fMRI) was undertaken. The presence of brain activation following innocuous brushing of an insensate region below-injury (great toe) was analyzed in 23 people (19 males (83%), mean ± SD age 43 ± 13 years) with clinically complete (AIS A) SCI with (n = 13) and without (n = 10) below-level neuropathic pain and 21 people without SCI or pain (15 males (71%); mean ± SD age 41 ± 14 years). Location appropriate, significant fMRI brain activation was detected in 48% (n = 11/23) of subjects with clinically complete SCI from below-injury stimulation. No association was found between the presence of subclinical sensory pathways transmitting innocuous mechanical stimuli (dor...Continue Reading

References

Jul 1, 1992·Journal of the Neurological Sciences·A M SherwoodW B McKay
Nov 1, 1991·Paraplegia·R L WatersJ S Yakura
Jun 1, 1987·Paraplegia·M R Dimitrijevic
Jun 17, 1998·NeuroImage·A NakamuraR Kakigi
Mar 5, 1999·Spinal Cord·B A Kakulas
Dec 13, 2002·Brain : a Journal of Neurology·N B FinnerupT S Jensen
Feb 7, 2004·Acta Neurologica Scandinavica·N B FinnerupT S Jensen
Apr 28, 2004·NeuroImage·Paul M MaceyRonald M Harper
Sep 18, 2004·Neurorehabilitation and Neural Repair·W B McKayA M Sherwood
Jun 7, 2007·Journal of Rehabilitation Research and Development·Peter H EllawayGordana Savic
Jul 14, 2007·Experimental Neurology·Nanna B FinnerupTroels S Jensen
Aug 2, 2008·Brain : a Journal of Neurology·Gunnar WasnerElspeth McLachlan
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke A HendersonPhilip J Siddall
Feb 15, 2012·The Journal of Spinal Cord Medicine·Steven C KirshblumWilliam Waring
Nov 26, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nanna Brix FinnerupLars Werhagen
Mar 27, 2015·Journal of Rehabilitation Medicine·Amar AwadJohan Eriksson
Jun 17, 2015·Journal of Neurotrauma·Yury P GerasimenkoV Reggie Edgerton
Sep 24, 2015·The Journal of Pain : Official Journal of the American Pain Society·Catherine R JutzelerJohn L K Kramer

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Citations

Jun 12, 2018·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Radoje D ČobeljićDejan B Popović
May 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mariana Cardoso MeloAlcimar Barbosa Soares
May 8, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rani Shiao, Corinne A Lee-Kubli
Aug 14, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Dario PfyfferPatrick Freund
Jun 14, 2019·Frontiers in Neuroscience·Morry SilbersteinMary P Galea
Jun 17, 2021·Human Brain Mapping·Vincent HuynhLars Michels
Jul 10, 2021·Science Progress·Can ZhaoJia-Sheng Rao

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