New experimental observation on the relationship of selenium and diabetes mellitus

Biological Trace Element Research
Xi-Qun ShengHui-Bi Xu

Abstract

Selenium shows insulin-mimic properties in vitro and in vivo. However, in this study, a high dose of 4 mg/kg/d selenite orally administered to the alloxan-induced diabetic Kun-Ming mice for 4 wk failed to reduce hyperglycemia. Se contents in plasma and tissues such as the liver, kidney, spleen, and brain were determined and the thiobarbituric acid-reactive substances (TBARS) levels were investigated. The results showed that alloxan-induced diabetes did not cause a significant decrease in Se levels in plasma and the above tissues compared to the normal control, but selenite treatment significantly increased Se levels in plasma, liver, and brain of the selenite-treated diabetic mice compared to the nontreated diabetic mice. In addition, selenite treatment for diabetic mice reduced the TBARS levels in red blood cells (RBCs) compared to the normal and improved the glutathione peroxidase (GSH-Px) levels in RBCs significantly compared to the diabetic control. In conclusion, this study demonstrated that although oral administration of a high dose of selenite had no hypoglycemic effect on diabetic mice in 4 wk, selenite treatment still maintained the antioxidant beneficial effect on the diabetic mice. This study shed more light on the ...Continue Reading

Citations

Dec 2, 2008·Biological & Pharmaceutical Bulletin·Nilda Berenice de Vargas BarbosaCristina Wayne Nogueira
Nov 18, 2008·Chemico-biological Interactions·Anna KiersztanJadwiga Bryla
Jul 8, 2008·The Journal of Nutritional Biochemistry·Andreas S MuellerJosef Pallauf
Sep 18, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N B V BarbosaC W Nogueira
Sep 13, 2006·Chemico-biological Interactions·N B V BarbosaC W Nogueira
Jun 22, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Xi-Qun ShengHui-Bi Xu
Sep 3, 2017·Polish Journal of Veterinary Sciences·K ŻarczyńskaP Sobiech
Sep 2, 2018·Diabetes/metabolism Research and Reviews·Miji KimJesse Roth
Sep 10, 2009·Free Radical Research·Andreas S MuellerJosef Pallauf

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