PMID: 9433706Jan 20, 1998Paper

New findings concerning vertebrate porin

Die Naturwissenschaften
Friedrich P Thinnes, S Reymann

Abstract

Eukaryotic porin can be considered to be a good candidate for forming the channel component of the protein complex which, depending on the approach used, may realize its expression either as the outwardly-rectifying depolarization-induced chloride channel or as the volume-sensitive organic osmolyte-anion channel. As a basis for this proposition, we point to a series of correspondences in properties between mammalian porin and the ORDIC channel complex. Specifically, mammalian porin is expressed in the plasmalemma of different cells and chloride channels can be blocked by anti-human porin antibodies in astrocytes and endothelial cells. There is an indication of colocalisation of human porin and the cystic fibrosis (CF) gene product, CFTR, in the apical region of epithelial cells. The primary structure of porin from a CF patient was found to be normal. Cytosol and amniotic fluid fractions influence the channel characteristics of mammalian porin. Channel-active mammalian porin binds ATP and the stilbene disulphonate grouping of the chloride channel inhibitor DIDS. Human porin in black membranes is a pathway for taurine, and biogenic polyamines reduce the voltage dependence of human porin. Assuming the relationship between human po...Continue Reading

Citations

Nov 25, 2000·The International Journal of Biochemistry & Cell Biology·C SchwarzerN Hilschmann
May 16, 2002·The International Journal of Biochemistry & Cell Biology·Christian SchwarzerNorbert Hilschmann
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·P SteinackerN Hilschmann
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Friedrich P Thinnes
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Meera SridharanRandy S Sprague
Feb 20, 2013·Molecular Genetics and Metabolism·Friedrich P Thinnes
Mar 17, 2009·Molecular Genetics and Metabolism·Friedrich P Thinnes
Feb 27, 2007·Molecular Genetics and Metabolism·Friedrich P Thinnes
Feb 16, 2006·Journal of Neurochemistry·James E Olson, Eduardo Martinho
Oct 21, 2015·Frontiers in Aging Neuroscience·Friedrich P Thinnes
Feb 18, 2004·Biochimica Et Biophysica Acta·Edson J MarquesOleg V Krasilnikov
Jan 26, 2010·Molecular Genetics and Metabolism·Friedrich P Thinnes
Dec 14, 2011·American Journal of Physiology. Cell Physiology·Sean P ParsonsJan D Huizinga
Jun 11, 2004·American Journal of Physiology. Cell Physiology·Chi-Wai DoMortimer M Civan
Jul 18, 2018·International Journal of Molecular Sciences·Magdalena BachmannLuigi Leanza

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