New focus of Kyasanur Forest disease virus activity in a tribal area in Kerala, India, 2014

Infectious Diseases of Poverty
Babasaheb V TandaleDevendra T Mourya

Abstract

Kyasanur Forest disease (KFD) is a febrile illness characterized by hemorrhages, and is reported endemic in the Shimoga district in Karnataka state, India. It is caused by the KFD virus (KFDV) of the family Flaviviridae, and is transmitted to monkeys and humans by Haemaphysalis ticks. We investigated a new focus of KFD among tribals in a reserve forest in Kerala state, India. A suspected case was defined as a person presenting with acute fever, headache, or myalgia. Human sera were collected and tested for KFDV RNA by real-time RT-PCR, RT-nPCR assay, and anti-KFDV IgM and IgG by ELISA. The index case was a tribal woman with febrile illness, severe myalgia, gum bleeding, and hematemesis. Anti-KFDV IgM antibody was detected in acute and convalescent sera of the index case along with IgG in the second serum. None of her family members reported fever. On verbal autopsy, two more fatal cases were identified as probable primary cases. Acute serum from a case in the second cluster was detected positive for KFDV RNA by real time RT-PCR (Ct = 32) and RT-nPCR. Sequences of E gene showed highest similarity of 98.0% with the KFDV W-377 isolate nucleotide and 100% identity with amino acid. Anti-KFDV IgM was detected in the serum of one fami...Continue Reading

References

Jul 1, 1959·American Journal of Public Health and the Nation's Health·T H WORKP N BHATT
Aug 10, 2012·Journal of Virological Methods·Devendra T MouryaAkhilesh C Mishra
Jan 25, 2013·Emerging Infectious Diseases·Gudadappa S KasabiSanjay M Mehendale
Jan 30, 2013·PLoS Neglected Tropical Diseases·Gudadappa S KasabiSanjay M Mehendale
Aug 28, 2013·Emerging Infectious Diseases·Devendra T MouryaShivanna Reddy
Jul 27, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pragya D YadavDevendra T Mourya

❮ Previous
Next ❯

Citations

Jul 1, 2016·Ticks and Tick-borne Diseases·Bradley W M CookSteven S Theriault
Oct 4, 2016·Ticks and Tick-borne Diseases·C SadanandaneP Jambulingam
Aug 2, 2016·PLoS Neglected Tropical Diseases·Bradley W M CookSteven S Theriault
Jan 18, 2018·Vector Borne and Zoonotic Diseases·Yogesh K GuravDevendra T Mourya
Nov 2, 2018·The Indian Journal of Medical Research·Ashok MunivenkatappaDevendra T Mourya
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Syed Z ShahShafiq Azam
Aug 20, 2015·Infectious Diseases of Poverty·Manoj V MurhekarBabasaheb V Tandale
Jul 27, 2017·Frontiers in Cellular and Infection Microbiology·Karen L MansfieldNicholas Johnson
Nov 2, 2019·The Indian Journal of Medical Research·Pragya D YadavDevendra T Mourya
Nov 17, 2020·QJM : Monthly Journal of the Association of Physicians·Nitin GuptaKavitha Saravu
May 24, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Triparna MajumdarPranita Gawande

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
ELISA

Software Mentioned

Sequencher

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Pragya D YadavDevendra T Mourya
© 2022 Meta ULC. All rights reserved