New foot-and-mouth disease vaccine, O JC-R, induce complete protection to pigs against SEA topotype viruses occurred in South Korea, 2014-2015

Journal of Veterinary Science
Hye Eun JoJong Hyeon Park

Abstract

Foot-and-mouth disease (FMD) is an acute epidemic that spreads rapidly among cattle and pigs. In 2014, in Korea, despite enforced vaccination, the type O Southeast Asia (SEA) topotype viruses (Mya-98 lineage) infected mainly cattle and pigs simultaneously, thereby causing enormous damage. If a vaccine that is completely protective against this FMD virus is developed and used, it can become a very important preventive measure in Asia, which is where this type of virus mainly circulates. The SEA topotype has been steadily evolving and transforming into new variations since it became epidemic in Asia. Therefore, it became necessary to develop a new vaccine that could provide protection against the FMD virus strain that was responsible for the 2014-2015 outbreak in Korea. This study aimed to develop a vaccine that would provide complete protection against the SEA topotype FMD virus to control sporadic FMD outbreaks, which occur despite the enforcement of vaccination, and to completely prevent virus shedding, thereby preventing the virus from spreading. The vaccine candidate virus developed in this study showed low pathogenicity and can be distinguished from the wild-type FMD virus strain. The developed vaccine was able to protect m...Continue Reading

References

Mar 2, 2012·Emerging Infectious Diseases·Nick J KnowlesDonald P King
Apr 19, 2013·Clinical and Experimental Vaccine Research·Jong-Hyeon Park
Nov 25, 2014·Emerging Infectious Diseases·Jong-Hyeon ParkByounghan Kim
May 23, 2015·Transboundary and Emerging Diseases·B P BritoA M Perez
Feb 13, 2016·Clinical and Experimental Vaccine Research·Jong-Hyeon ParkByounghan Kim
Jan 4, 2017·Veterinary Microbiology·Fayna Diaz-San SegundoTeresa de Los Santos
Sep 2, 2017·Journal of Veterinary Science·Min-Eun ParkJong-Hyeon Park
Nov 25, 2017·Journal of Veterinary Science·Jong-Hyeon ParkByounghan Kim
May 11, 2018·Transboundary and Emerging Diseases·Z ZhuX Liu

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Datasets Mentioned

BETA
KX162590

Methods Mentioned

BETA
transmission electron microscopy
Electron microscopy
enzyme-linked immunosorbent assay
ELISA
SP-ELISA

Software Mentioned

GraphPad
GraphPad Prism
GraphPad Instant

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