PMID: 11912008Mar 26, 2002Paper

New formulation of chemical peeling agent: 30% salicylic acid in polyethylene glycol. Absorption and distribution of 14C-salicylic acid in polyethylene glycol applied topically to skin of hairless mice

Journal of Dermatological Science
Setsuko UedaTetsuji Sudou

Abstract

Salicylic acid is used in chemical peeling procedures. However, they have caused many side effects, even salicylism. To achieve a salicylic acid peeling that would be safer for topical use, we recently developed a new formulation consisting of 30% salicylic acid in polyethylene glycol (PEG) vehicle. In an extension of our previous research, we studied the absorption of 30% salicylic acid labeled with 14C in PEG vehicle applied topically to the intact and damaged skin of male hairless mice. An ointment containing 3 mg salicylic acid in 10 mg vehicle was applied to both groups. In animals with intact skin, 1 h after application the plasma concentration of radioactivity was 1665.1 ng eq/ml, significantly lower than the 21437.6 ng eq/ml observed in mice with damaged skin. Microautoradiograms of intact skin showed that the level of radioactivity in the cornified cell layer was similar at 6 h after application. However, in damaged skin, the overall level of radioactivity showed a decrease by 3 h after application. In the carcasses remaining after the treated intact and damaged skin had been removed, 0.09 and 11.38% of the applied radioactivity remained, respectively. These findings confirm that 30% salicylic acid in PEG vehicle is li...Continue Reading

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Citations

Jan 8, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Yukiko HashimotoSetsuko Ueda
Mar 28, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Teruki DainichiMasutaka Furue
Apr 29, 2004·Dermatologic Therapy·Wendy E Roberts
Nov 10, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Azza Mahfouz Abdel MeguidHowida Omar
Mar 24, 2012·The Journal of Dermatology·UNKNOWN Committee for Guidelines of Care for Chemical Peeling
Jan 30, 2021·Ear, Nose, & Throat Journal·Nguyen Quynh AnhThongchai Bhongmakapat
Dec 24, 2005·The Journal of Investigative Dermatology·Teruki DainichiMasutaka Furue

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