New frontiers for platelet CD154

Experimental Hematology & Oncology
Antoine DewitteJ Ripoche

Abstract

The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.

References

Nov 1, 1992·Cancer Metastasis Reviews·K V HonnJ D Crissman
Jan 1, 1992·Seminars in Thrombosis and Hemostasis·K V HonnY Q Chen
Jul 15, 1991·Biochemical and Biophysical Research Communications·M YukawaT Mori
Apr 1, 1988·The Journal of Clinical Investigation·S KarpatkinB S Coller
Sep 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G J GasicC C Stewart
Dec 1, 1995·The Journal of Experimental Medicine·M J YellinL Chess
Oct 1, 1994·Seminars in Immunology·W C FanslowR J Armitage
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KarmannJ S Pober
Jul 1, 1995·The Journal of Experimental Medicine·D HollenbaughA Aruffo
Jun 1, 1995·European Journal of Immunology·D GrafR A Kroczek
Mar 31, 1995·The Journal of Biological Chemistry·G J MazzeiJ Y Bonnefoy
Mar 15, 1996·The Journal of Biological Chemistry·F PietravalleJ F Gauchat
Jul 12, 1996·Science·T G DiacovoU H von Andrian
Feb 1, 1997·The Journal of Clinical Investigation·S FunakoshiW J Murphy
Feb 7, 1998·The Journal of Experimental Medicine·T G DiacovoU H von Andrian
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·A S WeyrichG A Zimmerman
May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Aug 7, 1998·Atherosclerosis·F MachP Libby
Dec 16, 1998·Lancet·H M PinedoJ Folkman
Oct 8, 1999·The Journal of Clinical Investigation·K KatoT J Kipps
Jan 27, 2000·Journal of Leukocyte Biology·C van Kooten, J Banchereau
Mar 7, 2001·Cellular and Molecular Life Sciences : CMLS·U Schönbeck, P Libby
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L BorsigA Varki
Dec 12, 2001·Circulation Research·U Schönbeck, P Libby
Mar 5, 2002·Nature Medicine·Patrick AndréDenisa D Wagner
May 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·John DoukasGlenn F Pierce
May 29, 2002·Experimental Hematology·Monika Baj-KrzyworzekaMariusz Z Ratajczak
Jun 19, 2002·Circulation·Lisa Nannizzi-AlaimoHerman K Gold
Jul 27, 2002·The Lancet Oncology·G F NashA K Kakkar
Aug 21, 2002·Circulation·Patrick AndréDavid R Phillips
Sep 24, 2002·Seminars in Cell & Developmental Biology·Sarah M King, Guy L Reed
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Dec 19, 2002·Cancer Gene Therapy·Alex W Tong, Marvin J Stone
Dec 20, 2002·Nature·Carl Nathan
Jan 22, 2003·Journal of the American College of Cardiology·Anne G SembAnton F H Stalenhoef
Mar 15, 2003·The Journal of Biological Chemistry·Maria Chiara DeregibusGiovanni Camussi

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Citations

Apr 14, 2016·Journal of Cellular Biochemistry·Claire RigothierJean Ripoche
Aug 5, 2016·Physiological Reviews·Elizabeth A MiddletonGuy A Zimmerman
Jan 1, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Damir SimicMonicah Otieno
Mar 13, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea Magrone, Emilio Jirillo
Feb 23, 2019·Clinical Chemistry·Romain MeddebAlain R Thierry
Aug 12, 2018·Journal of Cellular Biochemistry·Jamshid TabeshpourAmirhossein Sahebkar
Oct 19, 2019·Research and Practice in Thrombosis and Haemostasis·Charlotte GrosdidierMatthias Canault
Aug 9, 2017·Mediators of Inflammation·Julien VilleneuveSébastien Lepreux
Jul 30, 2021·Frontiers in Oncology·Attila BraunElmina Mammadova-Bach

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Methods Mentioned

BETA
ELISA

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