New frontiers: harnessing pivotal advances in microbial engineering for the biosynthesis of plant-derived terpenoids.

Current Opinion in Biotechnology
Michael S BelcherJay D Keasling

Abstract

Terpenoids are a vast and diverse class of molecules with industrial and medicinal importance. The majority of these molecules are produced across kingdom Plantae via specialized metabolism. Microorganisms, mainly Escherichia coli and Saccharomyces cerevisiae, have become choice platforms for the biosynthesis of terpenoids due to recent advances in synthetic biology and metabolic engineering. New techniques for gene discovery have expanded our search space for novel terpene synthesis pathways and unlocked unrealized potential for the microbial production of more complex derivatives. Additionally, numerous advances in host and pathway engineering have allowed for the production of terpenoids requiring oxidation and glycosylation, effectively expanding the potential target space. These advances will lay the foundation for the microbial biosynthesis of a seemingly infinite domain of terpenoids with varying applications.

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Citations

Jan 26, 2021·Frontiers in Pharmacology·François ChassagneCassandra L Quave
Nov 19, 2020·Plants·Dmitriy N ShurpikIvan I Stoikov
Apr 9, 2020·Journal of Agricultural and Food Chemistry·So-Hee SonJu Young Lee
May 4, 2021·Medicinal Research Reviews·Zhimin HuLuqi Huang
May 29, 2021·Applied Microbiology and Biotechnology·Yachao ChenChun Li
Jun 19, 2021·Chemical Society Reviews·Dong YiUwe T Bornscheuer
Aug 12, 2021·Journal of Agricultural and Food Chemistry·Jie MaiXiao-Jun Ji
Aug 26, 2021·Metabolic Engineering Communications·Erika ArvayKeith Tyo
Aug 31, 2021·RSC Chemical Biology·Joanna C SadlerStephen Wallace

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