Dec 4, 2012

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures

Nucleic Acids Research
Ian SillitoeChristine A Orengo

Abstract

CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.

  • References26
  • Citations126

References

  • References26
  • Citations126

Citations

Mentioned in this Paper

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Conserved Sequence
Gene Products, Protein
Tertiary Protein Structure
Structural Genomics
Genomics
Protein Structure Databases
Molecular Sequence Annotation
Protein Folding, Globular
Homologous Gene

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