PMID: 22339358Feb 22, 2012Paper

New gene therapy strategies for cancer treatment: a review of recent patents

Recent Patents on Anti-cancer Drug Discovery
Raúl OrtizAntonia Aránega

Abstract

Cancer is the second leading cause of death in the Western world. The limited successes of available treatments for cancer mean that new strategies need to be developed. The possibility of modifying the cancer cell with the introduction of genetic material opens the way to a new approach based on gene therapy. There are still many technical difficulties to be overcome, but recent advances in the molecular and cellular biology of gene transfer have made it likely that gene therapy will soon start to play an increasing role in clinical practice, particularly in the treatment of cancer. Gene therapy will probably be the therapeutic option in cases in which conventional treatments such as surgery, radiotherapy and chemotherapy have failed. The development of modified vectors, and an improved understanding of interactions between the vector and the human host, are generating inventions that are being protected by patents due to the considerable interest of industry for their possible commercialization. We review the latest strategies, patented and/or under clinical trial, in cancer gene therapy. These include patents that cover the use of modified vectors to increase the security and specificity, recombining adenovirus that leads to...Continue Reading

Citations

May 1, 2013·International Journal of Nanomedicine·Jian-Xin ZhangSheng-Chun Dang
Sep 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nian-feng SunAn-bin Hu
Oct 11, 2014·Acta Biochimica Et Biophysica Sinica·Kai ZhangYang Jiang
Sep 10, 2013·Surgical Oncology Clinics of North America·Hagop Youssoufian, Jonathan Lewis
Mar 30, 2013·Biochemical and Biophysical Research Communications·Ying ZhaoShu Wang
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Jan 1, 2014·Journal of Digestive Diseases·Wen Ping XuWei Fen Xie
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May 10, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sarah UrnauerChristine Spitzweg
Aug 3, 2012·Immunotherapy·Teresa Freire, Eduardo Osinaga
Nov 28, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Nafiseh Nafisi FardArian Rahimi
Aug 23, 2019·Genes·Byung Chull AnMyung Jun Chung
Sep 29, 2019·World Journal of Gastrointestinal Oncology·Hsi-Lung Hsieh, Ming-Ming Tsai
Aug 6, 2019·Frontiers in Endocrinology·Urša KovačTadeja Režen
May 1, 2019·Journal of Medical Internet Research·Ming HuangLixia Yao
Jul 3, 2018·Oncology Letters·Tinglu LiHe Huang

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