New glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber

Journal of Natural Products
Shamil Sh AfiyatullovG B Elyakov

Abstract

Four new diterpene glycosides, virescenosides R (1), S (2), T (3), and U (4), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of HRFABMS, 1D and 2D NMR (1H, 13C, DEPT, COSY-45, COSY-RCT, HSQC, HMBC, and NOESY spectra), and the results of acidic hydrolysis as 19-O-[beta-D-glucopyranosyl(1-->6)-beta-d-altropyranosyl]-isopimara-7,15-diene-2alpha,3beta-diol (1), 19-O-beta-D-altropyranosyl-3-oxo-isopimara-8(14),15-diene-7alpha-ol (2), 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8,15-diene (3), and 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8(14),15-diene (4). The cytotoxic activity of the virescenosides was examined.

References

Aug 1, 1970·European Journal of Biochemistry·N Cagnoli-BellavitaZ Baskevitch
Jun 28, 2000·Journal of Natural Products·S S AfiyatullovG B Elyakov
May 25, 2002·Journal of Natural Products·Shamil Sh AfiyatullovGeorge B Elyakov

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Citations

Sep 30, 2005·Natural Product Reports·James R Hanson
Feb 3, 2006·Natural Product Reports·John W BluntMichèle R Prinsep
Jul 21, 2006·Natural Product Research·Shamil Sh AfiyatullovTatyana A Kuznetsova
Oct 16, 2010·Marine Drugs·Rainer Ebel
Jan 31, 2006·Journal of Natural Products·Claudia M BootPhillip Crews
Oct 10, 2006·The Journal of Antibiotics·Jae-Hyuk JangYoshikazu Shizuri
Jan 31, 2020·Frontiers in Chemistry·Kunlong LiHuaming Tao
Sep 23, 2006·Journal of Natural Products·Jae-Hyuk JangYoshikazu Shizuri

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