New half sandwich Ru(II) coordination compounds for anticancer activity

Dalton Transactions : an International Journal of Inorganic Chemistry
Ioannis BratsosEnzo Alessio

Abstract

With the aim of expanding the structure-activity relationship investigation, the series of Ru(II) half sandwich coordination compounds of the type [Ru([9]aneS3)(chel)(L)](n+) previously described by us (where [9]aneS3 is the neutral face-capping ligand 1,4,7-trithiacyclononane, chel is a neutral or anonic chelating ligand, L = Cl(-) or dmso-S, n = 0-2) was extended to 1,4,7-triazacyclononane ([9]aneN3). In addition, new neutral N-N, and anionic N-O and O-O chelating ligands, i.e. dach (trans-1,2-diaminocyclohexane), pic(-) (picolinate), and acac(-) (acetylacetonate), were investigated in combination with both [9]aneS3 and [9]aneN3. Overall, ten new half-sandwich complexes were prepared and fully characterized and their chemical behaviour in aqueous solution was established. The single-crystal X-ray structures of eight of them, including the versatile precursor [Ru([9]aneN3)(dmso-S)(2)Cl]Cl (9), were also determined. The results of in vitro antiproliferative tests performed on selected compounds against MDA-MB-231 human mammary carcinoma cells confirmed that, in this series, only compounds that hydrolyse the monodentate ligand at a reasonable rate show moderate activity, provided that the chelate ligand is a hydrogen bond donor.

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Citations

Mar 23, 2013·Inorganic Chemistry·Aimee J GambleAdrian C Whitwood
Aug 31, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gan-Jian LinYun-Jun Liu
Oct 1, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xiangwen LiaoMingpei Liu
Dec 3, 2014·Chemico-biological Interactions·Katja TravenTea Lanišnik Rižner
Mar 31, 2015·Journal of Molecular Modeling·Rafael R do NascimentoHelena M Petrilli
Feb 9, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Dejan LazićAna Rilak
Apr 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ying FuPeter J Sadler
Jul 1, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Jakob KljunIztok Turel
Apr 9, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lykourgos ChiniadisAthanasios Papakyriakou

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