PMID: 2100797Dec 1, 1990Paper

New heterocyclic systems for thiophene-2-thiolates--synthesis and biological activity

Die Pharmazie
D Briel

Abstract

Dicyanketendithiolae reacts with equimolar amounts of halogenmethans, substituted with electron withdrawing groups, to give thiophene-2-thiolates. These compounds are used for the preparation of thieno[2,3-b]thiophenes, including several functional groups in 2- and 5-position. Anellation of 1,3-oxazin-, pyrimidin-, 1,2,3-triazin- or 1,4-oxazepin-cycles give hitherto unknown tri- and tetracyclic ring systems. Some of synthetised compounds show biological activity.

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