PMID: 2497094May 1, 1989Paper

New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation

International Journal of Radiation Oncology, Biology, Physics
C ThomasM Guichard

Abstract

The effects of two new perfluorochemical emulsions based on F-66E and PFOB which carry, in combination with carbogen, more oxygen than Fluosol-DA 20% were investigated on a human tumor xenograft (HRT18). Tumor bearing mice were pretreated with 15 ml/kg of F-66E emulsion (50 w/v%) or PFOB (100 w/v%) emulsion in the presence of carbogen for 1 hr prior to and during irradiation. F-66E emulsion was non toxic in vitro. In vivo, the dose modifying factor was 1.8 for mice pretreated with carbogen and F-66E emulsion whereas it was 1.6 for carbogen-breathing mice. Results with PFOB emulsion were similar to those obtained with F-66E emulsion. The effect of F-66E emulsion was studied using a fractionated radiation treatment: 12 Gy were delivered in 6 fractions of 2 Gy with an interval of 8 hrs between fractions. A single dose of F-66E emulsion was injected before the first irradiation. Surviving fractions were 0.35 for air-breathing mice, 0.091 for carbogen-breathing mice and 0.099 for carbogen-breathing mice pretreated with F-66E emulsion. These results showed that carbogen alone or carbogen plus F-66E or PFOB emulsion were very efficient even with low doses of radiation.

Citations

May 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S SternM Guichard
Mar 1, 1993·The Journal of Pharmacy and Pharmacology·P K BentleyK C Lowe
Feb 1, 1991·International Journal of Radiation Biology·C ThomasM Guichard
Jun 1, 1992·International Journal of Radiation Biology·S RockwellC G Irvin
Oct 16, 2007·Cancer Treatment Reviews·Minghua YuRuijuan Xiu
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M Guichard
May 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L Vitu-LoasM Guichard
Sep 21, 2016·Journal of Translational Medicine·Linfeng XuHongqian Guo
Sep 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M SimonM Guichard
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·S RockwellJ J Fischer
Mar 1, 1994·International Journal of Radiation Biology·L M MartinM Guichard
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·M GuichardB Luboinski

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