PMID: 8960910Dec 1, 1996Paper

New highly polymorphic microsatellite marker in linkage disequilibrium with HLA-B

Human Immunology
M C GrimaldiB Crouau-Roy

Abstract

The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized approximately 25-kb centromeric to the gene HLA-B and 10-kb telomeric to the gene MICA. Twelve alleles defined by length were found in a sample of French Basques, with the PIC being 0.82. A detailed haplotype analysis was performed to investigate the association between this microsatellite and two others markers of the region (HLA-B gene and TNF region microsatellite). The 10 haplotypes with the highest estimated frequencies show evidence of a gametic association or linkage disequilibrium. A very strong association between the expressed HLA-B polymorphism and microsatellite alleles was also revealed in this sample and confirmed in the workshop cells lines of the Fourth Asia-Oceania Histocompatibility Workshop. This marker can be used in the fine mapping of this region and the association with some alleles of HLA-B may allow the replacement of HLA-B typing at least in a preliminary study. Moreover, these studies suppor...Continue Reading

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Citations

Jan 5, 2002·Human Immunology·K Y CheongP Price
Dec 1, 1996·Human Immunology·M Carrington, J Wade
Mar 1, 1997·Tissue Antigens·A FoissacA Cambon-Thomsen
Dec 6, 1997·Tissue Antigens·L LinE Mignot
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
Nov 1, 2008·BMC Genomics·Maxime BonhommeBrigitte Crouau-Roy
Jul 21, 2000·Tissue Antigens·A FoissacA Cambon-Thomsen
Oct 12, 2007·Genes and Immunity·S D'AlfonsoP Momigliano-Richiardi
Aug 8, 2009·International Journal of Immunogenetics·C Sens-AbuázarV Sperandio-Roxo
Mar 19, 2008·Molecular Ecology·Natasja G de GrootRonald E Bontrop
Jun 4, 2010·International Journal of Immunogenetics·S García-ObregónJ A Peña

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